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    Skap1 src family associated phosphoprotein 1 [ Mus musculus (house mouse) ]

    Gene ID: 78473, updated on 24-Jun-2016
    Official Symbol
    Skap1provided by MGI
    Official Full Name
    src family associated phosphoprotein 1provided by MGI
    Primary source
    MGI:MGI:1925723
    See related
    Ensembl:ENSMUSG00000057058 Vega:OTTMUSG00000001774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scap1; Skap-55; 1700091G21Rik
    Orthologs
    Location:
    11; 11 D
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (96464570..96759622)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (96325905..96620936)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene 11529 Neighboring gene predicted gene, 38960 Neighboring gene predicted gene, 38448 Neighboring gene sorting nexin 11 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene chromobox 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3/SH2 adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune response-activating signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    src kinase-associated phosphoprotein 1
    Names
    ortholog of human src family associated phosphoprotein 1 SCAP1
    src family-associated phosphoprotein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033186.3NP_001028358.1  src kinase-associated phosphoprotein 1 isoform 1

      See identical proteins and their annotated locations for NP_001028358.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AK040068, AK137942
      Consensus CDS
      CCDS25301.1
      UniProtKB/Swiss-Prot
      Q3UUV5
      UniProtKB/TrEMBL
      Q3V3I1
      Related
      ENSMUSP00000099443, OTTMUSP00000001877, ENSMUST00000103154, OTTMUST00000003558
      Conserved Domains (2) summary
      cd12044
      Location:294346
      SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
      cd13380
      Location:108213
      PH_Skap1; Src kinase-associated phosphoprotein 1 Pleckstrin homology (PH) domain
    2. NM_001177898.1NP_001171369.1  src kinase-associated phosphoprotein 1 isoform 2

      See identical proteins and their annotated locations for NP_001171369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons, one of which changes the reading frame, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK040068, AK137942, AK138030
      Consensus CDS
      CCDS48892.1
      UniProtKB/Swiss-Prot
      Q3UUV5
      UniProtKB/TrEMBL
      Q3V3I1
      Related
      ENSMUSP00000098090, OTTMUSP00000037399, ENSMUST00000100521, OTTMUST00000072578
      Conserved Domains (2) summary
      cd13380
      Location:108213
      PH_Skap1; Src kinase-associated phosphoprotein 1 Pleckstrin homology (PH) domain
      cl17036
      Location:278306
      SH3; Src Homology 3 domain superfamily
    3. NM_001177899.1NP_001171370.1  src kinase-associated phosphoprotein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate, in-frame exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK040068, AK137942, BC150764, BY723539
      Consensus CDS
      CCDS48891.1
      UniProtKB/Swiss-Prot
      Q3UUV5
      UniProtKB/TrEMBL
      B2RWZ1, Q3V3I1
      Related
      ENSMUSP00000071445, OTTMUSP00000037400, ENSMUST00000071510, OTTMUST00000072579
      Conserved Domains (2) summary
      cd12044
      Location:278330
      SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
      cd13380
      Location:108213
      PH_Skap1; Src kinase-associated phosphoprotein 1 Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      96464570..96759622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534508.3XP_006534571.1  

      Conserved Domains (2) summary
      cd13380
      Location:108213
      PH_Skap1; Src kinase-associated phosphoprotein 1 Pleckstrin homology (PH) domain
      cl17036
      Location:294322
      SH3; Src Homology 3 domain superfamily
    2. XM_017314838.1XP_017170327.1  

    3. XM_017314839.1XP_017170328.1