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    Tsc2 tuberous sclerosis 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24855, updated on 29-Jul-2016
    Official Symbol
    Tsc2provided by RGD
    Official Full Name
    tuberous sclerosis 2provided by RGD
    Primary source
    RGD:3908
    See related
    Ensembl:ENSRNOG00000011375
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rc
    Summary
    acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD, Feb 2006]
    Orthologs
    Location:
    10q12
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13962006..13996684, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (13778990..13813725, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551976 Neighboring gene RAB26, member RAS oncogene family Neighboring gene polycystic kidney disease 1 Neighboring gene nth-like DNA glycosylase 1 Neighboring gene SLC9A3 regulator 2 Neighboring gene neuropeptide W

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell projection organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of TOR signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase B signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport into plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    NOT Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    TSC1-TSC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    TSC1-TSC2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    TSC1-TSC2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    NOT nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tuberin
    Names
    Tsc2
    renal carcinoma
    tuberous sclerosis 2 homolog protein
    tuberous sclerosis 2 protein homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012680.3NP_036812.2  tuberin

      See identical proteins and their annotated locations for NP_036812.2

      Status: PROVISIONAL

      Source sequence(s)
      U24150
      UniProtKB/Swiss-Prot
      P49816
      Related
      ENSRNOP00000016221, ENSRNOT00000016221
      Conserved Domains (3) summary
      pfam02145
      Location:15641750
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin; Tuberin
      pfam11864
      Location:54466
      DUF3384; Domain of unknown function (DUF3384)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      13962006..13996684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245909.3XP_006245971.2  

    2. XM_017597022.1XP_017452511.1  

    3. XM_017597020.1XP_017452509.1  

    4. XM_017597019.1XP_017452508.1  

    5. XM_017597027.1XP_017452516.1  

    6. XM_017597026.1XP_017452515.1  

    7. XM_017597024.1XP_017452513.1  

    8. XM_017597025.1XP_017452514.1  

    9. XM_017597023.1XP_017452512.1  

    10. XM_017597021.1XP_017452510.1  

    11. XM_008767544.2XP_008765766.1  

      Conserved Domains (3) summary
      pfam02145
      Location:15041693
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:492845
      Tuberin; Tuberin
      pfam11864
      Location:1413
      DUF3384; Domain of unknown function (DUF3384)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      13301129..13335713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)