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    Gc group specific component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24384, updated on 4-Jul-2015
    Official Symbol
    Gcprovided by RGD
    Official Full Name
    group specific componentprovided by RGD
    Primary source
    RGD:2667
    See related
    Ensembl:ENSRNOG00000003119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DBP; VDB; Vdbp; DBP02
    Summary
    transports vitamin D and vitamin D metabolites [RGD, Feb 2006]
    Orthologs
    See Gc in MapViewer
    Location:
    14p22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (20267023..20302577)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (20173467..20209021)

    Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1, motif 3 Neighboring gene neuropeptide FF receptor 2 Neighboring gene signal recognition particle 19 kDa protein pseudogene Neighboring gene LRRGT00190

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcidiol binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcidiol binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    vitamin D binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vitamin D binding TAS
    Traceable Author Statement
    more info
    PubMed 
    vitamin transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    lactation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    vitamin D metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    vitamin D metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    vitamin transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood microparticle IEA
    Inferred from Electronic Annotation
    more info
     
    blood microparticle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    vitamin D-binding protein
    Names
    gc-globulin
    NP_036696.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012564.3NP_036696.2  vitamin D-binding protein precursor

      See identical proteins and their annotated locations for NP_036696.2

      Status: VALIDATED

      Source sequence(s)
      BC078891
      UniProtKB/TrEMBL
      Q68FY4
      Related
      ENSRNOP00000004174, ENSRNOT00000004174
      Conserved Domains (3) summary
      smart00103
      Location:209387
      ALBUMIN; serum albumin
      cd00015
      Location:26206
      ALBUMIN; Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; ...
      pfam09164
      Location:405472
      VitD-bind_III; Vitamin D binding protein, domain III

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

      Range
      20267023..20302577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000082.1 Alternate Rn_Celera

      Range
      17992337..18027605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)