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    FGF3 fibroblast growth factor 3 [ Homo sapiens (human) ]

    Gene ID: 2248, updated on 28-Jun-2015
    Official Symbol
    FGF3provided by HGNC
    Official Full Name
    fibroblast growth factor 3provided by HGNC
    Primary source
    HGNC:HGNC:3681
    See related
    HPRD:01289; MIM:164950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT2; HBGF-3
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
    Orthologs
    See FGF3 in Epigenomics, MapViewer
    Location:
    11q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (69809968..69819424, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69624736..69634192, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 7 pseudogene Neighboring gene fibroblast growth factor 4 Neighboring gene uncharacterized LOC101928443 Neighboring gene uncharacterized LOC105369371

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    NHGRI GWA Catalog
    Genome-wide association study identifies five new breast cancer susceptibility loci.
    NHGRI GWA Catalog
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
     
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    organ induction IEA
    Inferred from Electronic Annotation
    more info
     
    otic vesicle formation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    post-anal tail morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    semicircular canal morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    fibroblast growth factor 3
    Names
    fibroblast growth factor 3
    FGF-3
    INT-2 proto-oncogene protein
    V-INT2 murine mammary tumor virus integration site oncogene homolog
    fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
    heparin-binding growth factor 3
    murine mammary tumor virus integration site 2, mouse
    oncogene INT2
    proto-oncogene Int-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009016.1 RefSeqGene

      Range
      5001..14457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005247.2NP_005238.1  fibroblast growth factor 3 precursor

      See identical proteins and their annotated locations for NP_005238.1

      Status: REVIEWED

      Source sequence(s)
      X14445
      Consensus CDS
      CCDS8195.1
      UniProtKB/Swiss-Prot
      P11487
      Conserved Domains (1) summary
      cd00058
      Location:46181
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      69809968..69819424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      69507656..69517018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)