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TRIM24 tripartite motif containing 24 [ Homo sapiens (human) ]

Gene ID: 8805, updated on 22-Nov-2014
Official Symbol
TRIM24provided by HGNC
Official Full Name
tripartite motif containing 24provided by HGNC
Primary source
HGNC:HGNC:11812
See related
Ensembl:ENSG00000122779; HPRD:04556; MIM:603406; Vega:OTTHUMG00000155820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA
Summary
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
See TRIM24 in Epigenomics, MapViewer
Location:
7q32-q34
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (138460334..138585588)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138145079..138270333)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene prothymosin, alpha pseudogene Neighboring gene IMP (inosine monophosphate) dehydrogenase 1 pseudogene 3 Neighboring gene ribosomal protein S3a pseudogene 28 Neighboring gene SVOP-like Neighboring gene ribosomal protein L21 pseudogene 73 Neighboring gene ribosomal protein L17 pseudogene 27

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Papillary thyroid carcinoma
MedGen: C0238463 OMIM: 188550 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat binds to TIF1 in 293T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Androgen receptor activity, organism-specific biosystem
    Regulation of Androgen receptor activity
  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR in disease, organism-specific biosystemThe pathway 'Signaling by FGFR in disease' shows 'Signaling by FGFR mutants' in parallel with the wild-type pathway 'Signaling by FGFR', allowing users to compare disease and normal events. FGFR mut...
  • Signaling by FGFR mutants, organism-specific biosystem (from REACTOME)
    Signaling by FGFR mutants, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
  • Signaling by FGFR1 fusion mutants, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1 fusion mutants, organism-specific biosystem8p11 myeloproliferative syndrome (EMS) is an aggressive disorder that is associated with a translocation event at the FGFR1 gene on chromosome 8p11. Typical symptoms upon diagnosis include eosinophi...
  • Signaling by FGFR1 mutants, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1 mutants, organism-specific biosystemThe FGFR1 gene has been shown to be subject to activating mutations, chromosomal rearrangements and gene amplification leading to a variety of proliferative and developmental disorders depending on w...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
estrogen response element binding IDA
Inferred from Direct Assay
more info
PubMed 
ligand-dependent nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
receptor binding TAS
Traceable Author Statement
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
regulation of vitamin D receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nuclear euchromatin IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
perichromatin fibrils IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transcription intermediary factor 1-alpha
Names
transcription intermediary factor 1-alpha
TIF1-alpha
RING finger protein 82
tripartite motif-containing 24
E3 ubiquitin-protein ligase TRIM24
transcriptional intermediary factor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023286.1 

    Range
    5001..130255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003852.3NP_003843.3  transcription intermediary factor 1-alpha isoform b

    See proteins identical to NP_003843.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF119042, AK075306, BC028689, CB988362
    Consensus CDS
    CCDS47720.1
    UniProtKB/TrEMBL
    A0A024R784
    UniProtKB/Swiss-Prot
    O15164
    Related
    ENSP00000390829, OTTHUMP00000208725, ENST00000415680, OTTHUMT00000341820
    Conserved Domains (7) summary
    cd05502
    Location:866973
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:266392
    BBC; B-Box C-terminal domain
    smart00336
    Location:158194
    BBOX; B-Box-type zinc finger
    smart00818
    Location:432519
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cd00021
    Location:221259
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:5582
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00628
    Location:794837
    PHD; PHD-finger
  2. NM_015905.2NP_056989.2  transcription intermediary factor 1-alpha isoform a

    See proteins identical to NP_056989.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA844662, AK075306, BC028689, CB988362
    Consensus CDS
    CCDS5847.1
    UniProtKB/Swiss-Prot
    O15164
    Conserved Domains (6) summary
    cd05502
    Location:9001007
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:266392
    BBC; B-Box C-terminal domain
    smart00336
    Location:158194
    BBOX; B-Box-type zinc finger
    cd00021
    Location:221259
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:5582
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00628
    Location:828871
    PHD; PHD-finger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    132454177..132579352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    138460334..138585588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    138078355..138203624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)