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HCVgp1 polyprotein [ Hepatitis C virus ]

Gene ID: 951475, updated on 7-Dec-2014
Gene symbol
HCVgp1
Gene description
polyprotein
Locus tag
HCVgp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Hepatitis C virus (serotype: 1a, isolate: H77)
Lineage
Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Hepacivirus
Sequence:
NC_004102.1 (342..9377)

NC_004102.1Genomic Context describing neighboring genes Neighboring gene protein F

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description
Names
polyprotein
core protein
E1 protein
E2 protein
p7 protein
NS2 protein
NS3 protease/helicase
NS4A protein
NS4B protein
NS5A protein
NS5B RNA-dependent RNA polymerase

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004102.1 

    Range
    342..9377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_671491.1 polyprotein [Hepatitis C virus]

    See proteins identical to NP_671491.1

    Status: REVIEWED

    Conserved Domains (17) summary
    pfam01001
    Location:17281921
    HCV_NS4b; Hepatitis C virus non-structural protein NS4b
    pfam01539
    Location:193382
    HCV_env; Hepatitis C virus envelope glycoprotein E1
    pfam01542
    Location:116190
    HCV_core; Hepatitis C virus core protein
    pfam01560
    Location:386729
    HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
    pfam02907
    Location:10561204
    Peptidase_S29; Hepatitis C virus NS3 protease
    pfam01543
    Location:2115
    HCV_capsid; Hepatitis C virus capsid protein
    pfam08301
    Location:20682168
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam12941
    Location:21792420
    HCV_NS5a_C; HCV NS5a protein C-terminal region
    pfam01538
    Location:8111005
    HCV_NS2; Hepatitis C virus non-structural protein NS2
    smart00487
    Location:12281355
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:12241351
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:13781455
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd01699
    Location:25362818
    RNA_dep_RNAP; RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are ...
    pfam00998
    Location:24232934
    RdRP_3; Viral RNA dependent RNA polymerase
    pfam01006
    Location:16581711
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a
    pfam01506
    Location:19741996
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam08300
    Location:20062067
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
  2. NP_751919.1 core protein

    Conserved Domains (2) summary
    pfam01542
    Location:116190
    HCV_core; Hepatitis C virus core protein
    pfam01543
    Location:2115
    HCV_capsid; Hepatitis C virus capsid protein
  3. NP_751920.1 E1 protein

    Conserved Domains (1) summary
    pfam01539
    Location:2191
    HCV_env; Hepatitis C virus envelope glycoprotein E1
  4. NP_751921.1 E2 protein

    Conserved Domains (1) summary
    pfam01560
    Location:3346
    HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
  5. NP_751922.1 p7 protein

    Conserved Domains (1) summary
    cl09930
    Location:2348
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
  6. NP_751923.1 NS2 protein

    Conserved Domains (1) summary
    pfam01538
    Location:2196
    HCV_NS2; Hepatitis C virus non-structural protein NS2
  7. NP_803144.1 NS3 protease/helicase

    Conserved Domains (4) summary
    pfam02907
    Location:30178
    Peptidase_S29; Hepatitis C virus NS3 protease
    smart00487
    Location:202329
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:198325
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:352429
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
  8. NP_751925.1 NS4A protein

    Conserved Domains (1) summary
    pfam01006
    Location:154
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a
  9. NP_751926.1 NS4B protein

    Conserved Domains (1) summary
    pfam01001
    Location:17210
    HCV_NS4b; Hepatitis C virus non-structural protein NS4b
  10. NP_751927.1 NS5A protein

    Conserved Domains (4) summary
    pfam08301
    Location:96196
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam12941
    Location:207448
    HCV_NS5a_C; HCV NS5a protein C-terminal region
    pfam01506
    Location:224
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam08300
    Location:3495
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
  11. NP_751928.1 NS5B RNA-dependent RNA polymerase

    Conserved Domains (2) summary
    cd01699
    Location:116398
    RNA_dep_RNAP; RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are ...
    pfam00998
    Location:3514
    RdRP_3; Viral RNA dependent RNA polymerase