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    ACRBP acrosin binding protein [ Homo sapiens (human) ]

    Gene ID: 84519, updated on 8-Aug-2016
    Official Symbol
    ACRBPprovided by HGNC
    Official Full Name
    acrosin binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:17195
    See related
    Ensembl:ENSG00000111644 HPRD:16322; MIM:608352; Vega:OTTHUMG00000168715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT23; SP32; OY-TES-1
    Summary
    The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    12p13.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (6638076..6647414, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6747241..6756594, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene uncharacterized LOC105369631 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene inhibitor of growth family member 4 Neighboring gene zinc finger protein 384

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: LPAR5

    Homology

    Clone Names

    • FLJ51160

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    acrosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    acrosin-binding protein
    Names
    ACRBP
    cancer/testis antigen 23
    cancer/testis antigen OY-TES-1
    proacrosin binding protein sp32
    testicular tissue protein Li 10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032489.2NP_115878.2  acrosin-binding protein precursor

      See identical proteins and their annotated locations for NP_115878.2

      Status: REVIEWED

      Source sequence(s)
      AB051833
      Consensus CDS
      CCDS8554.1
      UniProtKB/Swiss-Prot
      Q8NEB7
      UniProtKB/TrEMBL
      A0A140VJD6
      Related
      ENSP00000229243, OTTHUMP00000239242, ENST00000229243, OTTHUMT00000400703
      Conserved Domains (1) summary
      pfam07222
      Location:1211
      PBP_sp32; Proacrosin binding protein sp32

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      6638076..6647414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      6746238..6755578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)