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IL5RA interleukin 5 receptor, alpha [ Homo sapiens (human) ]

Gene ID: 3568, updated on 12-May-2015
Official Symbol
IL5RAprovided by HGNC
Official Full Name
interleukin 5 receptor, alphaprovided by HGNC
Primary source
HGNC:HGNC:6017
See related
Ensembl:ENSG00000091181; HPRD:00998; MIM:147851; Vega:OTTHUMG00000090245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL5R; CD125; CDw125; HSIL5R3
Summary
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
Orthologs
See IL5RA in MapViewer
Location:
3p26-p24
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (3066324..3110374, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (3108008..3152058, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene contactin 4 Neighboring gene uncharacterized LOC105376925 Neighboring gene CNTN4 antisense RNA 1 Neighboring gene tRNA nucleotidyl transferase, CCA-adding, 1 Neighboring gene uncharacterized LOC105376928 Neighboring gene cereblon

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog
Genome-wide association study of antibody response to smallpox vaccine.
NHGRI GWA Catalog
Genome-wide association study of the age of onset of childhood asthma.
NHGRI GWA Catalog
Impact of ancestry and common genetic variants on QT interval in African Americans.
NHGRI GWA Catalog
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • G beta:gamma signalling through PI3Kgamma, organism-specific biosystem (from REACTOME)
    G beta:gamma signalling through PI3Kgamma, organism-specific biosystemPI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predomi...
  • G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
    G-protein beta:gamma signalling, organism-specific biosystemThe classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known tha...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
    GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
    Inflammatory Response Pathway, organism-specific biosystem
    Inflammatory Response Pathway
  • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
    Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
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  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
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  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26560

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-5 receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
interleukin-5-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space TAS
Traceable Author Statement
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
interleukin-5 receptor subunit alpha
Names
interleukin-5 receptor subunit alpha
CD125 antigen
IL-5 receptor subunit alpha
IL-5R subunit alpha
interleukin 5 receptor type 3
interleukin-5 receptor alpha chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029547.1 RefSeqGene

    Range
    5001..49051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000564.4NP_000555.2  interleukin-5 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_000555.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).
    Source sequence(s)
    AC022002, AC024060, AK304256, BX118481, DB222974, M96652, X61176
    Consensus CDS
    CCDS2559.1
    UniProtKB/TrEMBL
    A0A024R2C8
    UniProtKB/Swiss-Prot
    Q01344
    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. NM_001243099.1NP_001230028.1  interleukin-5 receptor subunit alpha isoform 4 precursor

    See identical proteins and their annotated locations for NP_001230028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC022002, AC024060, AK304256, BX118481
    Consensus CDS
    CCDS58813.1
    UniProtKB/Swiss-Prot
    Q01344
    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  3. NM_175724.2NP_783851.1  interleukin-5 receptor subunit alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_783851.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' end region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC024060, BI520196, DB229011, M96651, X62156
    Consensus CDS
    CCDS46739.1
    UniProtKB/Swiss-Prot
    Q01344
    Related
    ENSP00000400400, OTTHUMP00000206894, ENST00000430514, OTTHUMT00000337538
    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  4. NM_175725.2NP_783852.1  interleukin-5 receptor subunit alpha isoform 3 precursor

    See identical proteins and their annotated locations for NP_783852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' end region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC024060, BI520196, DB229011, M75914, X62156
    Consensus CDS
    CCDS2560.1
    UniProtKB/Swiss-Prot
    Q01344
    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  5. NM_175726.3NP_783853.1  interleukin-5 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_783853.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal segment within the 5' UTR, as compared to variant 1. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC022002, AK304256, BX118481, DB222974, M96652, X61176
    Consensus CDS
    CCDS2559.1
    UniProtKB/TrEMBL
    A0A024R2C8
    UniProtKB/Swiss-Prot
    Q01344
    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  6. NM_175727.2NP_783854.1  interleukin-5 receptor subunit alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_783854.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal segment within the 5' UTR, and differs in the 3' end region, when compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BI520196, DB229011, M96651, X62156
    Consensus CDS
    CCDS46739.1
    UniProtKB/Swiss-Prot
    Q01344
    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  7. NM_175728.2NP_783855.1  interleukin-5 receptor subunit alpha isoform 3 precursor

    See identical proteins and their annotated locations for NP_783855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an internal segment within the 5' UTR, and differs in the 3' end region, when compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC027599, BI520196, DB229011, M75914, X62156
    Consensus CDS
    CCDS2560.1
    UniProtKB/Swiss-Prot
    Q01344
    UniProtKB/TrEMBL
    Q8NHV7
    Related
    ENSP00000373358, OTTHUMP00000115373, ENST00000383846, OTTHUMT00000206686
    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    3066324..3110374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533677.1XP_011531979.1  

    See identical proteins and their annotated locations for XP_011531979.1

    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. XM_011533678.1XP_011531980.1  

    See identical proteins and their annotated locations for XP_011531980.1

    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  3. XM_011533679.1XP_011531981.1  

    Conserved Domains (1) summary
    pfam09240
    Location:128236
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    3057999..3102013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)