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NCBP1 nuclear cap binding protein subunit 1, 80kDa [ Homo sapiens (human) ]

Gene ID: 4686, updated on 7-Dec-2014
Official Symbol
NCBP1provided by HGNC
Official Full Name
nuclear cap binding protein subunit 1, 80kDaprovided by HGNC
Primary source
HGNC:HGNC:7658
Locus tag
RP11-546O6.1
See related
Ensembl:ENSG00000136937; HPRD:02717; MIM:600469; Vega:OTTHUMG00000020332
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCBP; Sto1; CBP80
Summary
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]
See NCBP1 in Epigenomics, MapViewer
Location:
9q34.1
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (97633423..97673748)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100395705..100436030)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene tudor domain containing 7 Neighboring gene tropomodulin 1 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 Neighboring gene xeroderma pigmentosum, complementation group A Neighboring gene uncharacterized LOC102724595 Neighboring gene keratin 18 pseudogene 13 Neighboring gene papillary thyroid carcinoma susceptibility candidate 2 (non-protein coding)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
NHGRI GWA Catalog
  • Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem (from REACTOME)
    Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystemThis event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of th...
  • Cap binding complex, organism-specific biosystem (from KEGG)
    Cap binding complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
  • Cap binding complex, conserved biosystem (from KEGG)
    Cap binding complex, conserved biosystemStructural complex; Genetic information processing; Spliceosome
  • Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem (from REACTOME)
    Cleavage of Growing Transcript in the Termination Region, organism-specific biosystemThis section includes the cleavage of both polyadenylated and non-polyadenylated transcripts. In the former case polyadenylation has to precede transcript cleavage, while in the latter case there is ...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Formation of HIV elongation complex in the absence of HIV Tat, organism-specific biosystem (from REACTOME)
    Formation of HIV elongation complex in the absence of HIV Tat, organism-specific biosystem
    Formation of HIV elongation complex in the absence of HIV Tat
  • Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem (from REACTOME)
    Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystemThis HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the gener...
  • Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
    Formation of RNA Pol II elongation complex, organism-specific biosystemTFIIS is a transcription factor involved in different phases of transcription, occurring in a major ubiquitous form and other tissue specific forms. TFIIS stimulates RNA Pol II complex out of elonga...
  • Formation of the Early Elongation Complex, organism-specific biosystem (from REACTOME)
    Formation of the Early Elongation Complex, organism-specific biosystemTranscription elongation by RNA polymerase II (RNAPII) is controlled by a number of trans-acting transcription elongation factors as well as by cis-acting elements. Transcription elongation is a rat...
  • Formation of the HIV-1 Early Elongation Complex, organism-specific biosystem (from REACTOME)
    Formation of the HIV-1 Early Elongation Complex, organism-specific biosystemThis HIV-1 event was inferred from the corresponding human RNA Poll II transcription event. The details relevant to HIV-1 are described below. Formation of the early elongation complex involves hypo...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • HIV Transcription Elongation, organism-specific biosystem (from REACTOME)
    HIV Transcription Elongation, organism-specific biosystemIn the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription ...
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
    Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystemNonsense-mediated decay has been observed with mRNAs that do not have an exon junction complex (EJC) downstream of the termination codon (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-An...
  • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
    Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Processing of Capped Intronless Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intronless Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Processing of Intronless Pre-mRNAs, organism-specific biosystem (from REACTOME)
    Processing of Intronless Pre-mRNAs, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3' processing consists of two steps: The mRNA is first cleaved ...
  • RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Pre-transcription Events, organism-specific biosystem
    RNA Polymerase II Pre-transcription Events
  • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription, organism-specific biosystem
    RNA Polymerase II Transcription
  • RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription Elongation, organism-specific biosystemThe mechanisms governing the process of elongation during eukaryotic mRNA synthesis are being unraveled by recent studies. These studies have led to the expected discovery of a diverse collection of ...
  • RNA Polymerase II Transcription Termination, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription Termination, organism-specific biosystemThe detailed annotation of this section will be completed in the next release.
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, organism-specific biosystem (from REACTOME)
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, organism-specific biosystemThere are two well-documented trans-acting factors required for histone pre-mRNA processing. These are:1 Stem-loop binding protein (SLBP), also termed hairpin binding protein (HBP). This 32 kDa pro...
  • SLBP independent Processing of Histone Pre-mRNAs, organism-specific biosystem (from REACTOME)
    SLBP independent Processing of Histone Pre-mRNAs, organism-specific biosystemThis class of mRNAs is expressed from genes that lack introns yet the transcripts end in polyA tails. These tails are formed by a mechanism similar to that for pre-mRNAs containing introns. It is ...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Tat-mediated elongation of the HIV-1 transcript, organism-specific biosystem (from REACTOME)
    Tat-mediated elongation of the HIV-1 transcript, organism-specific biosystemThe Tat protein is a viral transactivator protein that regulates HIV-1 gene expression by controlling RNA Pol II-mediated elongation (reviewed in Karn 1999; Taube et al. 1999; Liou et al. 2004; Barb...
  • Transcription of the HIV genome, organism-specific biosystem (from REACTOME)
    Transcription of the HIV genome, organism-specific biosystemExpression of the integrated HIV-1 provirus is dependent on the host cell Pol II transcription machinery, but is regulated in critical ways by HIV-1 Tat and Rev proteins. The long terminal repeats (L...
  • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
    Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
  • Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing.
  • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
  • Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystemTransport of mature mRNAs derived from intronless transcripts require some of the same protein complexes as mRNAs derived from intron containing complexes, including TAP and Aly/Ref. However a number...
  • Transport of the SLBP Dependant Mature mRNA, organism-specific biosystem (from REACTOME)
    Transport of the SLBP Dependant Mature mRNA, organism-specific biosystemTransport of U7 snRNP and stem-loop binding protein (SLBP) processed mRNA.
  • Transport of the SLBP independent Mature mRNA, organism-specific biosystem (from REACTOME)
    Transport of the SLBP independent Mature mRNA, organism-specific biosystemTransport of the SLBP independent Mature mRNA through the nuclear pore.
  • mRNA 3'-end processing, organism-specific biosystem (from REACTOME)
    mRNA 3'-end processing, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first ...
  • mRNA Capping, organism-specific biosystem (from REACTOME)
    mRNA Capping, organism-specific biosystemThe 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures. The cap is thought to influence splicing of the first intron, and is bound by 'cap-binding' proteins, CBP80 a...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
  • mRNA Splicing - Minor Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Minor Pathway, organism-specific biosystemThe splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that ...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • snRNP Assembly, organism-specific biosystem (from REACTOME)
    snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC2087

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA cap binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
PubMed 
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
RNA metabolic process TAS
Traceable Author Statement
more info
 
RNA splicing TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
 
histone mRNA metabolic process TAS
Traceable Author Statement
more info
 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
mRNA cleavage IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA metabolic process TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
ncRNA metabolic process TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
positive regulation of mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of viral transcription TAS
Traceable Author Statement
more info
 
regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal snRNP assembly TAS
Traceable Author Statement
more info
 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mRNA cap binding complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear cap binding complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear cap-binding protein subunit 1
Names
nuclear cap-binding protein subunit 1
NCBP 80 kDa subunit
80 kDa nuclear cap-binding protein
nuclear cap binding protein subunit 1, 80kD

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002486.4NP_002477.1  nuclear cap-binding protein subunit 1

    See proteins identical to NP_002477.1

    Status: REVIEWED

    Source sequence(s)
    AL445531, BC001450, CA418527, DB086376
    Consensus CDS
    CCDS6728.1
    UniProtKB/TrEMBL
    A0A024R179
    UniProtKB/Swiss-Prot
    Q09161
    Related
    ENSP00000364289, OTTHUMP00000021753, ENST00000375147, OTTHUMT00000053337
    Conserved Domains (3) summary
    pfam09088
    Location:304470
    MIF4G_like; MIF4G like
    smart00543
    Location:28240
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam09090
    Location:485754
    MIF4G_like_2; MIF4G like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    97633423..97673748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251997.2XP_005252054.1  

    See proteins identical to XP_005252054.1

    Conserved Domains (3) summary
    pfam09088
    Location:237403
    MIF4G_like; MIF4G like
    smart00543
    Location:9173
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam09090
    Location:418687
    MIF4G_like_2; MIF4G like
  2. XM_006717118.1XP_006717181.1  

    See proteins identical to XP_006717181.1

    Conserved Domains (2) summary
    pfam09088
    Location:114280
    MIF4G_like; MIF4G like
    pfam09090
    Location:295564
    MIF4G_like_2; MIF4G like
  3. XM_006717119.1XP_006717182.1  

    See proteins identical to XP_006717182.1

    Conserved Domains (2) summary
    pfam09088
    Location:114280
    MIF4G_like; MIF4G like
    pfam09090
    Location:295564
    MIF4G_like_2; MIF4G like

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    100542138..100582465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    69996714..70037070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)