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    SLC22A11 solute carrier family 22 member 11 [ Homo sapiens (human) ]

    Gene ID: 55867, updated on 23-Aug-2016
    Official Symbol
    SLC22A11provided by HGNC
    Official Full Name
    solute carrier family 22 member 11provided by HGNC
    Primary source
    HGNC:HGNC:18120
    See related
    Ensembl:ENSG00000168065 HPRD:06161; MIM:607097; Vega:OTTHUMG00000045142
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OAT4; hOAT4
    Summary
    The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Orthologs
    Location:
    11q13.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (64555601..64572875)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64323098..64339002)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996455 Neighboring gene uncharacterized LOC105369342 Neighboring gene solute carrier family 22 member 12 Neighboring gene neurexin 2 Neighboring gene uncharacterized LOC107984337

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    NHGRI GWA Catalog
    Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
    NHGRI GWA Catalog
    Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC34282

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    organic anion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    urate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    solute carrier family 22 member 11
    Names
    organic anion transporter 4
    solute carrier family 22 (organic anion/cation transporter), member 11
    solute carrier family 22 (organic anion/urate transporter), member 11

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307985.1NP_001294914.1  solute carrier family 22 member 11 isoform 2

      See identical proteins and their annotated locations for NP_001294914.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AA331094, AK129930, AP001092, BI051409, BX094958, DC339422
      Consensus CDS
      CCDS76425.1
      UniProtKB/Swiss-Prot
      Q9NSA0
      Related
      ENSP00000366809, OTTHUMP00000069174, ENST00000377585, OTTHUMT00000141960
      Conserved Domains (2) summary
      cd06174
      Location:119277
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11351
      2A0119; cation transport protein
    2. NM_018484.3NP_060954.1  solute carrier family 22 member 11 isoform 1

      See identical proteins and their annotated locations for NP_060954.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA331094, AP001092, BC034384, BI051409, BX094958, DC339422
      Consensus CDS
      CCDS8074.1
      UniProtKB/Swiss-Prot
      Q9NSA0
      Related
      ENSP00000301891, OTTHUMP00000042651, ENST00000301891, OTTHUMT00000104886
      Conserved Domains (2) summary
      cd06174
      Location:119511
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11523
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      64555601..64572875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545167.1XP_011543469.1  

      Conserved Domains (1) summary
      cd06174
      Location:33378
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      64206220..64223495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)