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    Pkn1 protein kinase N1 [ Mus musculus (house mouse) ]

    Gene ID: 320795, updated on 13-Aug-2016
    Official Symbol
    Pkn1provided by MGI
    Official Full Name
    protein kinase N1provided by MGI
    Primary source
    MGI:MGI:108022
    See related
    Ensembl:ENSMUSG00000057672 Vega:OTTMUSG00000025931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DBK; Pkn; PAK1; PRK1; Stk3; Prkcl1; F730027O18Rik
    Orthologs
    Location:
    8 C2; 8 40.22 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (83666533..83699179, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (86193995..86223025, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene prostaglandin E receptor 1 (subtype EP1) Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 Neighboring gene microRNA 1668 Neighboring gene adhesion G protein-coupled receptor E5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP-Rho binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rac GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone kinase activity (H3-T11 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligand-dependent nuclear receptor transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-T11 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    renal system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic, membrane-bounded vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase N1
    Names
    protein kinase C-like 1
    protein kinase C-like PKN
    protein-kinase C-related kinase 1
    serine-threonine protein kinase N
    serine/threonine kinase 3
    NP_001186522.1
    NP_796236.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199593.1NP_001186522.1  serine/threonine-protein kinase N1 isoform 1

      See identical proteins and their annotated locations for NP_001186522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC164432, AK089431, AK149649, CX568360
      Consensus CDS
      CCDS57627.1
      UniProtKB/Swiss-Prot
      P70268
      Related
      ENSMUSP00000116235, OTTMUSP00000031748, ENSMUST00000144258, OTTMUST00000064019
      Conserved Domains (6) summary
      PTZ00263
      Location:621944
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd08687
      Location:397484
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:37103
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:126197
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cl00087
      Location:214286
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cd05589
      Location:624948
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    2. NM_177262.4NP_796236.2  serine/threonine-protein kinase N1 isoform 2

      See identical proteins and their annotated locations for NP_796236.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR and 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC164432, BC052923, CX568360
      Consensus CDS
      CCDS22459.1
      UniProtKB/Swiss-Prot
      P70268
      Related
      ENSMUSP00000005616, OTTMUSP00000031688, ENSMUST00000005616, OTTMUST00000063925
      Conserved Domains (6) summary
      PTZ00263
      Location:616939
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd08687
      Location:392479
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:3298
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:121192
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:619943
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:209281
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      83666533..83699179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001778448.1 RNA Sequence

    2. XR_001778447.1 RNA Sequence