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    pdgfrb platelet-derived growth factor receptor, beta polypeptide [ Danio rerio (zebrafish) ]

    Gene ID: 559529, updated on 11-Jun-2016
    Official Symbol
    pdgfrbprovided by ZNC
    Official Full Name
    platelet-derived growth factor receptor, beta polypeptideprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030805-2
    See related
    Ensembl:ENSDARG00000100897
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    pdgfrb2
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    Location:
    chromosome: Un
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    104 current GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003335281.1 (85481..117389)
    104 current GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336495.1 (730..6404)
    103 previous assembly Zv9 (GCF_000002035.4) 14 NC_007125.5 (3463518..3495426)
    103 previous assembly Zv9 (GCF_000002035.4) Unplaced Scaffold NW_003336495.1 (730..6404)

    NW_003336495.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885838

    NW_003335281.1Genomic Context describing neighboring genes Neighboring gene homeobox protein CDX-1-like Neighboring gene caudal type homeobox 1a

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellum vasculature development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    platelet-derived growth factor receptor beta
    Names
    platelet-derived growth factor receptor beta 2
    NP_001177862.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190933.1NP_001177862.1  platelet-derived growth factor receptor beta

      See identical proteins and their annotated locations for NP_001177862.1

      Status: PROVISIONAL

      Source sequence(s)
      HM439112
      UniProtKB/TrEMBL
      D9MNA7
      Related
      ENSDARP00000138883, ENSDART00000167247
      Conserved Domains (4) summary
      smart00410
      Location:311393
      IG_like; Immunoglobulin like
      pfam07714
      Location:579935
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:301395
      Ig; Immunoglobulin domain
      cl21453
      Location:541939
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 104 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz10 Primary Assembly

    Genomic

    1. NW_003336495.1 Reference GRCz10 Primary Assembly

      Range
      730..6404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz10 Primary Assembly

    Genomic

    1. NW_003335281.1 Reference GRCz10 Primary Assembly

      Range
      85481..117389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)