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NADSYN1 NAD synthetase 1 [ Homo sapiens (human) ]

Gene ID: 55191, updated on 7-Dec-2014
Official Symbol
NADSYN1provided by HGNC
Official Full Name
NAD synthetase 1provided by HGNC
Primary source
HGNC:HGNC:29832
See related
Ensembl:ENSG00000172890; HPRD:16309; MIM:608285; Vega:OTTHUMG00000167375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]
See NADSYN1 in Epigenomics, MapViewer
Location:
11q13.4
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (71453171..71501538)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71164217..71212586)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC399923 Neighboring gene 7-dehydrocholesterol reductase Neighboring gene microRNA 6754 Neighboring gene S100 calcium binding protein A11 pseudogene 3 Neighboring gene keratin associated protein 5-7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10631, FLJ36703, FLJ40627

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ synthase (glutamine-hydrolyzing) activity TAS
Traceable Author Statement
more info
 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
NAD metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
vitamin metabolic process TAS
Traceable Author Statement
more info
 
water-soluble vitamin metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
glutamine-dependent NAD(+) synthetase
Names
glutamine-dependent NAD(+) synthetase
NAD(+) synthase
NAD(+) synthetase
glutamine-dependent NAD synthetase
NP_060631.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018161.4NP_060631.2  glutamine-dependent NAD(+) synthetase

    See proteins identical to NP_060631.2

    Status: VALIDATED

    Source sequence(s)
    AK022436, AW804480, BC003638, BC020977, BE730392, BI460954, BM554316, CB141878
    Consensus CDS
    CCDS8201.1
    UniProtKB/Swiss-Prot
    Q6IA69
    Related
    ENSP00000326424, OTTHUMP00000235817, ENST00000319023, OTTHUMT00000394356
    Conserved Domains (3) summary
    cd07570
    Location:6298
    GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
    PLN02339
    Location:3699
    PLN02339; NAD+ synthase (glutamine-hydrolysing)
    cd00553
    Location:327650
    NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    71453171..71501538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    71048194..71096600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    67457809..67506195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)