Display Settings:

Format

Send to:

Choose Destination

SFTPA2 surfactant protein A2 [ Homo sapiens (human) ]

Gene ID: 729238, updated on 21-Mar-2015
Official Symbol
SFTPA2provided by HGNC
Official Full Name
surfactant protein A2provided by HGNC
Primary source
HGNC:HGNC:10799
See related
Ensembl:ENSG00000185303; MIM:178642; Vega:OTTHUMG00000018566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSAP; PSPA; SP-A; SPA2; PSP-A; SFTP1; SPAII; COLEC5; SFTPA2B
Summary
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]
Annotation information
Note: In the NCBI Build 36 reference assembly, there were four SFTPA genes on chromosome 10, with the SFTPA1/SFTPA2 gene pair being centromeric to a SFTPA1B/SFTPA2B pair. In June 2009, the Genome Reference Consortium determined that the duplicated region containing one of these gene pairs is in error, and thus, only one SFTPA1/SFTPA2 pair is present in the GRCh37 reference assembly. [13 Feb 2013]
Orthologs
See SFTPA2 in MapViewer
Location:
10q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (79555852..79560459, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81315608..81320177, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 5A-like 1 Neighboring gene ribosomal protein S12 pseudogene 18 Neighboring gene mannose-binding lectin family member 3, pseudogene Neighboring gene surfactant protein A3, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • FOXA1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    FOXA1 transcription factor network, organism-specific biosystem
    FOXA1 transcription factor network
  • Pertussis, organism-specific biosystem (from KEGG)
    Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Pertussis, conserved biosystem (from KEGG)
    Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ50594, FLJ50597, FLJ51953, FLJ79091, FLJ93678, MGC133169, MGC133366, MGC189714, MGC189761

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pulmonary surfactant-associated protein A2
Names
pulmonary surfactant-associated protein A2
35 kDa pulmonary surfactant-associated protein
alveolar proteinosis protein
collectin 5
surfactant, pulmonary-associated protein A2A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013046.1 RefSeqGene

    Range
    5001..9556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098668.2NP_001092138.1  pulmonary surfactant-associated protein A2 precursor

    See proteins identical to NP_001092138.1

    Status: REVIEWED

    Source sequence(s)
    BX248123
    Consensus CDS
    CCDS41540.1
    UniProtKB/Swiss-Prot
    Q8IWL1
    Related
    ENSP00000361400, OTTHUMP00000019932, ENST00000372325, OTTHUMT00000048961
    Conserved Domains (2) summary
    cd03591
    Location:136248
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:28100
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    79555852..79560459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270132.3XP_005270189.1  

    See proteins identical to XP_005270189.1

    UniProtKB/Swiss-Prot
    Q8IWL1
    Conserved Domains (2) summary
    cd03591
    Location:136248
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:28100
    Collagen; Collagen triple helix repeat (20 copies)
  2. XM_005270131.3XP_005270188.1  

    See proteins identical to XP_005270188.1

    UniProtKB/Swiss-Prot
    Q8IWL1
    Conserved Domains (2) summary
    cd03591
    Location:136248
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:28100
    Collagen; Collagen triple helix repeat (20 copies)
  3. XM_005270128.2XP_005270185.1  

    Conserved Domains (2) summary
    cd03591
    Location:153265
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:45117
    Collagen; Collagen triple helix repeat (20 copies)
  4. XM_011540125.1XP_011538427.1  

    See proteins identical to XP_011538427.1

    Conserved Domains (2) summary
    cd03591
    Location:136248
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:28100
    Collagen; Collagen triple helix repeat (20 copies)
  5. XM_011540124.1XP_011538426.1  

    See proteins identical to XP_011538426.1

    Conserved Domains (2) summary
    cd03591
    Location:136248
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:28100
    Collagen; Collagen triple helix repeat (20 copies)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    81598238..81602793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)