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    BLVRA biliverdin reductase A [ Homo sapiens (human) ]

    Gene ID: 644, updated on 25-Aug-2016
    Official Symbol
    BLVRAprovided by HGNC
    Official Full Name
    biliverdin reductase Aprovided by HGNC
    Primary source
    HGNC:HGNC:1062
    See related
    Ensembl:ENSG00000106605 HPRD:11229; MIM:109750; Vega:OTTHUMG00000128953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BVR; BLVR; BVRA
    Summary
    The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
    Orthologs
    Location:
    7p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (43758153..43807342)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43798272..43846941)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC100506895 Neighboring gene serine/threonine kinase 17a Neighboring gene cytochrome c oxidase assembly factor 1 homolog Neighboring gene uncharacterized LOC107986727 Neighboring gene uncharacterized LOC102724946 Neighboring gene URGCP-MRPS24 readthrough Neighboring gene uncharacterized LOC107986791 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene upregulator of cell proliferation Neighboring gene tubulin gamma 1 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Heme degradation, organism-specific biosystem (from REACTOME)
      Heme degradation, organism-specific biosystemMost of the heme degraded in humans comes from hemoglobin. Approximately 6-8 grams of hemoglobin is degraded daily which is equivalent to approximately 300 milligrams of heme per day. Heme is not rec...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of porphyrins, organism-specific biosystem (from REACTOME)
      Metabolism of porphyrins, organism-specific biosystemPorphyrins are heterocyclic macrocycles, consisting of four pyrrole subunits (tetrapyrrole) linked by four methine (=CH-) bridges. The extensive conjugated porphyrin macrocycle is chromatic and the n...
    • Porphyrin and chlorophyll metabolism, organism-specific biosystem (from KEGG)
      Porphyrin and chlorophyll metabolism, organism-specific biosystem
      Porphyrin and chlorophyll metabolism
    • Porphyrin and chlorophyll metabolism, conserved biosystem (from KEGG)
      Porphyrin and chlorophyll metabolism, conserved biosystem
      Porphyrin and chlorophyll metabolism
    • heme degradation, organism-specific biosystem (from BIOCYC)
      heme degradation, organism-specific biosystemThe heme degradation pathway in animals ensures the recycling of iron. The first enzyme in this pathway, : HS02027-MONOMER, catayzes the opening of the tetrapyrrole macrocycle of : PROTOHEME, forming...
    • heme degradation, conserved biosystem (from BIOCYC)
      heme degradation, conserved biosystemThe heme degradation pathway in animals ensures the recycling of iron. The first enzyme in this pathway, |FRAME: HS02027-MONOMER|, catayzes the opening of the tetrapyrrole macrocycle of |FRAME: Heme-...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    biliverdin reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    biliverdin reductase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    heme catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    biliverdin reductase A
    Names
    BVR A
    biliverdin-IX alpha-reductase
    testis tissue sperm-binding protein Li 61n
    NP_000703.2
    NP_001240752.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031876.1 RefSeqGene

      Range
      5001..53670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000712.3NP_000703.2  biliverdin reductase A precursor

      See identical proteins and their annotated locations for NP_000703.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BM710258, CA418616, U34877, X93086
      Consensus CDS
      CCDS5472.1
      UniProtKB/Swiss-Prot
      P53004
      UniProtKB/TrEMBL
      A0A140VJF4
      Related
      ENSP00000265523, OTTHUMP00000159196, ENST00000265523, OTTHUMT00000250932
      Conserved Domains (3) summary
      COG0673
      Location:58140
      MviM; Predicted dehydrogenase [General function prediction only]
      pfam01408
      Location:18125
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:133243
      Biliv-reduc_cat; Biliverdin reductase, catalytic
    2. NM_001253823.1NP_001240752.1  biliverdin reductase A precursor

      See identical proteins and their annotated locations for NP_001240752.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK291862, BM710258, CA418616
      Consensus CDS
      CCDS5472.1
      UniProtKB/Swiss-Prot
      P53004
      UniProtKB/TrEMBL
      A0A140VJF4
      Related
      ENSP00000385757, OTTHUMP00000207534, ENST00000402924, OTTHUMT00000339006
      Conserved Domains (3) summary
      COG0673
      Location:58140
      MviM; Predicted dehydrogenase [General function prediction only]
      pfam01408
      Location:18125
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:133243
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      43758153..43807342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515474.2XP_011513776.1  

      See identical proteins and their annotated locations for XP_011513776.1

      UniProtKB/Swiss-Prot
      P53004
      UniProtKB/TrEMBL
      A0A140VJF4
      Conserved Domains (3) summary
      COG0673
      Location:58140
      MviM; Predicted dehydrogenase [General function prediction only]
      pfam01408
      Location:18125
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:133243
      Biliv-reduc_cat; Biliverdin reductase, catalytic
    2. XM_017012520.1XP_016868009.1  

      Conserved Domains (3) summary
      COG0673
      Location:58140
      MviM; Predicted dehydrogenase [General function prediction only]
      pfam01408
      Location:18125
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:133243
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      43802192..43850836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)