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    Best2 bestrophin 2 [ Mus musculus (house mouse) ]

    Gene ID: 212989, updated on 13-Aug-2016
    Official Symbol
    Best2provided by MGI
    Official Full Name
    bestrophin 2provided by MGI
    Primary source
    MGI:MGI:2387588
    See related
    Ensembl:ENSMUSG00000052819 Vega:OTTMUSG00000061399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vmd2l1
    Orthologs
    Location:
    8; 8 C3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (85007202..85014531, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (87531101..87538307, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene jun B proto-oncogene Neighboring gene hook microtubule tethering protein 2 Neighboring gene arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) Neighboring gene RIKEN cDNA 2310036O22 gene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chloride channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to chloride channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    chloride transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    membrane depolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sensory perception of smell IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chloride channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    bestrophin-2
    Names
    vitelliform macular dystrophy 2-like protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130194.1NP_001123666.1  bestrophin-2

      See identical proteins and their annotated locations for NP_001123666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC163703, AY450428, BY096795
      Consensus CDS
      CCDS52621.1
      UniProtKB/Swiss-Prot
      Q8BGM5
      UniProtKB/TrEMBL
      A0A0R4J0P0
      Related
      ENSMUSP00000053408, OTTMUSP00000077702, ENSMUST00000059072, OTTMUST00000149824
      Conserved Domains (1) summary
      pfam01062
      Location:8314
      Bestrophin; Bestrophin, RFP-TM, chloride channel

    RNA

    1. NR_052011.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC163703, AY450428

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      85007202..85014531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530820.1XP_006530883.1  

      See identical proteins and their annotated locations for XP_006530883.1

      UniProtKB/Swiss-Prot
      Q8BGM5
      UniProtKB/TrEMBL
      A0A0R4J0P0
      Related
      ENSMUSP00000147837, OTTMUSP00000077703, ENSMUST00000209421, OTTMUST00000149825
      Conserved Domains (1) summary
      pfam01062
      Location:8314
      Bestrophin; Bestrophin, RFP-TM, chloride channel
    2. XM_011248341.2XP_011246643.1  

      Conserved Domains (1) summary
      pfam01062
      Location:32288
      Bestrophin; Bestrophin, RFP-TM, chloride channel