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    TTC37 tetratricopeptide repeat domain 37 [ Homo sapiens (human) ]

    Gene ID: 9652, updated on 25-Jul-2015
    Official Symbol
    TTC37provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 37provided by HGNC
    Primary source
    HGNC:HGNC:23639
    See related
    Ensembl:ENSG00000198677; HPRD:11079; MIM:614589; Vega:OTTHUMG00000121165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ski3; THES; KIAA0372
    Summary
    This gene encodes a protein with twenty tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Mutations in this gene are associated with trichohepatoenteric syndrome. [provided by RefSeq, Jul 2010]
    Orthologs
    See TTC37 in Epigenomics, MapViewer
    Location:
    5q15
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (95463895..95555005, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (94799599..94890709, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379089 Neighboring gene family with sequence similarity 81, member B Neighboring gene chromosome 14 open reading frame 166 pseudogene Neighboring gene arylsulfatase family, member K Neighboring gene G protein-coupled receptor 150

    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • Ski complex, organism-specific biosystem (from KEGG)
      Ski complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Ski complex, conserved biosystem (from KEGG)
      Ski complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0372, MGC32587

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Ski complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptionally active chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tetratricopeptide repeat protein 37
    Names
    SKI3 homolog
    TPR repeat protein 37
    thespin
    tricho-hepatic-enteric syndrome protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023414.1 RefSeqGene

      Range
      5001..96111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_173

    mRNA and Protein(s)

    1. NM_014639.3NP_055454.1  tetratricopeptide repeat protein 37

      See identical proteins and their annotated locations for NP_055454.1

      Status: REVIEWED

      Source sequence(s)
      AB002370
      Consensus CDS
      CCDS4072.1
      UniProtKB/Swiss-Prot
      Q6PGP7
      Related
      ENSP00000351596, OTTHUMP00000149977, ENST00000358746, OTTHUMT00000241651
      Conserved Domains (5) summary
      pfam00515
      Location:861894
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:275335
      TPR_11; TPR repeat
      pfam13432
      Location:1072
      TPR_16; Tetratricopeptide repeat
      TIGR02917
      Location:3221272
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:568644
      TPR; putative protein binding surface [polypeptide binding]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      95463895..95555005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_948312.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      94232235..94323386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)