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    CGN cingulin [ Homo sapiens (human) ]

    Gene ID: 57530, updated on 18-Aug-2016
    Official Symbol
    CGNprovided by HGNC
    Official Full Name
    cingulinprovided by HGNC
    Primary source
    HGNC:HGNC:17429
    See related
    Ensembl:ENSG00000143375 HPRD:10827; MIM:609473; Vega:OTTHUMG00000012497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Orthologs
    Location:
    1q21
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (151510859..151538692)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151483331..151511168)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene proteasome subunit beta 4 Neighboring gene pogo transposable element with ZNF domain Neighboring gene RNA, Ro-associated Y4 pseudogene 25 Neighboring gene tuftelin 1 Neighboring gene microRNA 554 Neighboring gene ribosomal protein S10 pseudogene 6

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
      Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
    • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
      TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemIn normal cells and in the early stages of cancer development, signaling by TGF-beta plays a tumor suppressive role, as SMAD2/3:SMAD4-mediated transcription inhibits cell division by downregulating M...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ39281, KIAA1319, DKFZp779N1112

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell junction TAS
    Traceable Author Statement
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020770.2NP_065821.1  cingulin

      See identical proteins and their annotated locations for NP_065821.1

      Status: VALIDATED

      Source sequence(s)
      AF263462, AL365436, BC146657, BC152445, BP331021, CN359389
      Consensus CDS
      CCDS999.1
      UniProtKB/Swiss-Prot
      Q9P2M7
      Related
      ENSP00000271636, OTTHUMP00000014466, ENST00000271636, OTTHUMT00000034900
      Conserved Domains (3) summary
      pfam01576
      Location:3701152
      Myosin_tail_1; Myosin tail
      pfam11262
      Location:10901163
      Tho2; Transcription factor/nuclear export subunit protein 2
      cl23720
      Location:10231124
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      151510859..151538692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245365.4XP_005245422.1  

      See identical proteins and their annotated locations for XP_005245422.1

      UniProtKB/Swiss-Prot
      Q9P2M7
      Conserved Domains (3) summary
      pfam01576
      Location:3701152
      Myosin_tail_1; Myosin tail
      pfam11262
      Location:10901163
      Tho2; Transcription factor/nuclear export subunit protein 2
      cl23720
      Location:10231124
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RNA

    1. XR_921902.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      152879286..152906583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)