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    KCNK6 potassium two pore domain channel subfamily K member 6 [ Homo sapiens (human) ]

    Gene ID: 9424, updated on 14-Jun-2016
    Official Symbol
    KCNK6provided by HGNC
    Official Full Name
    potassium two pore domain channel subfamily K member 6provided by HGNC
    Primary source
    HGNC:HGNC:6281
    See related
    Ensembl:ENSG00000099337 HPRD:06803; MIM:603939; Vega:OTTHUMG00000182325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2
    Summary
    This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    19q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (38319814..38329014)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38810484..38819654)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kunitz type, 2 Neighboring gene chromosome 19 open reading frame 33 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene cation channel sperm associated auxiliary subunit gamma Neighboring gene proteasome 26S subunit, non-ATPase 8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human potassium channel, subfamily K, member 6 (KCNK6) at amino acid residues 42-43 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Phase 4 - resting membrane potential, organism-specific biosystem (from REACTOME)
      Phase 4 - resting membrane potential, organism-specific biosystemPhase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+...
    • Potassium Channels, organism-specific biosystem (from REACTOME)
      Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
    • Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), organism-specific biosystem (from REACTOME)
      Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), organism-specific biosystemTWIK channels exhibit very low current and comprise of TWIK1, TWIK2 and KCNK7 members. TWIK current may be low due to rapid recycling of the channels from the plasma membrane.
    • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
      Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...

    Homology

    Clone Names

    • FLJ12282

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    inward rectifier potassium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    potassium channel activity TAS
    Traceable Author Statement
    more info
     
    potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    cardiac conduction TAS
    Traceable Author Statement
    more info
     
    negative regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of resting membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    voltage-gated potassium channel complex TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    potassium channel subfamily K member 6
    Names
    K2P6.1 potassium channel
    TWIK-originated similarity sequence
    TWIK-originated sodium similarity sequence
    inward rectifying potassium channel protein TWIK-2
    potassium channel, two pore domain subfamily K, member 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004823.1NP_004814.1  potassium channel subfamily K member 6

      See identical proteins and their annotated locations for NP_004814.1

      Status: REVIEWED

      Source sequence(s)
      AF117708
      Consensus CDS
      CCDS12513.1
      UniProtKB/Swiss-Prot
      Q9Y257
      UniProtKB/TrEMBL
      B2RDS2
      Related
      ENSP00000263372, OTTHUMP00000268936, ENST00000263372, OTTHUMT00000460524
      Conserved Domains (1) summary
      pfam07885
      Location:91139
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      38319814..38329014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527526.1XP_011525828.1  

      See identical proteins and their annotated locations for XP_011525828.1

      UniProtKB/Swiss-Prot
      Q9Y257
      Conserved Domains (1) summary
      pfam07885
      Location:46122
      Ion_trans_2; Ion channel
    2. XM_017027506.1XP_016882995.1  

    3. XM_011527527.1XP_011525829.1  

      Conserved Domains (1) summary
      pfam07885
      Location:91108
      Ion_trans_2; Ion channel

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      38810843..38820013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)