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Cav1 caveolin 1, caveolae protein [ Mus musculus (house mouse) ]

Gene ID: 12389, updated on 21-Sep-2014
Official Symbol
Cav1provided by MGI
Official Full Name
caveolin 1, caveolae proteinprovided by MGI
Primary source
MGI:MGI:102709
See related
Ensembl:ENSMUSG00000007655; Vega:OTTMUSG00000024023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cav; Cav-1
See Cav1 in Epigenomics, MapViewer
Location:
6; 6 A2
Exon count:
6
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 6 NC_000072.6 (17306335..17341328)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D830026I12 gene Neighboring gene uncharacterized LOC102631703 Neighboring gene uncharacterized LOC102631779 Neighboring gene caveolin 2 Neighboring gene met proto-oncogene Neighboring gene capping protein (actin filament) muscle Z-line, alpha 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
caveola assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
caveola assembly ISO
Inferred from Sequence Orthology
more info
 
caveolin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to hyperoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosolic calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
endocytosis TAS
Traceable Author Statement
more info
PubMed 
inactivation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of protein location in cell ISO
Inferred from Sequence Orthology
more info
 
mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland involution IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JAK-STAT cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pinocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tyrosine phosphorylation of Stat5 protein IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tyrosine phosphorylation of Stat5 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitric oxide homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium ion transport into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metalloenzyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization involved in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of the force of heart contraction by chemical signal IGI
Inferred from Genetic Interaction
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen ISO
Inferred from Sequence Orthology
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
response to progesterone ISO
Inferred from Sequence Orthology
more info
PubMed 
skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISO
Inferred from Sequence Orthology
more info
 
caveola TAS
Traceable Author Statement
more info
PubMed 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular ISO
Inferred from Sequence Orthology
more info
 
lipid particle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
caveolin-1
Names
caveolin-1
caveolin, caveolae protein 1
caveolin, caveolae protein, 22 kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243064.1NP_001229993.1  caveolin-1 isoform 2

    See proteins identical to NP_001229993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB029930, AK028738, AW488080, CK622116
    Consensus CDS
    CCDS57410.1
    UniProtKB/Swiss-Prot
    P49817
    Related
    ENSMUSP00000111113, OTTMUSP00000028493, ENSMUST00000115453, OTTMUST00000058733
    Conserved Domains (1) summary
    pfam01146
    Location:3146
    Caveolin; Caveolin
  2. NM_007616.4NP_031642.1  caveolin-1 isoform 1

    See proteins identical to NP_031642.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC023173, AK003489, AK028738, AW488080, BY235137
    Consensus CDS
    CCDS19924.1
    UniProtKB/Swiss-Prot
    P49817
    Related
    ENSMUSP00000007799, OTTMUSP00000028492, ENSMUST00000007799, OTTMUST00000058732
    Conserved Domains (1) summary
    pfam01146
    Location:34177
    Caveolin; Caveolin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000072.6 

    Range
    17306335..17341328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504974.1XP_006505037.1  

    See proteins identical to XP_006505037.1

    UniProtKB/Swiss-Prot
    P49817
    Conserved Domains (1) summary
    pfam01146
    Location:34177
    Caveolin; Caveolin
  2. XM_006504975.1XP_006505038.1  

    See proteins identical to XP_006505038.1

    UniProtKB/Swiss-Prot
    P49817
    Conserved Domains (1) summary
    pfam01146
    Location:3146
    Caveolin; Caveolin
  3. XM_006504976.1XP_006505039.1  

    See proteins identical to XP_006505039.1

    UniProtKB/Swiss-Prot
    P49817
    Conserved Domains (1) summary
    pfam01146
    Location:3146
    Caveolin; Caveolin

Alternate Mm_Celera

Genomic

  1. AC_000028.1 

    Range
    17378800..17414674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)