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Il23a Interleukin 23, alpha subunit p19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 155140, updated on 24-Jan-2015
Official Symbol
Il23aprovided by RGD
Official Full Name
Interleukin 23, alpha subunit p19provided by RGD
Primary source
RGD:620873
See related
Ensembl:ENSRNOG00000003254
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
mouse homolog is a pro-inflammatory cytokine; high levels of expression may be associated with rheumatoid arthritis, psoriasis, and multiple sclerosis [RGD, Feb 2006]
Orthologs
See Il23a in MapViewer
Location:
7q11
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2710609..2712723, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (2689128..2691242, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene apolipoprotein F Neighboring gene signal transducer and activator of transcription 2 Neighboring gene PAN2 poly(A) specific ribonuclease subunit Neighboring gene canopy FGF signaling regulator 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Pertussis, organism-specific biosystem (from KEGG)
    Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Pertussis, conserved biosystem (from KEGG)
    Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Markers

Homology

Clone Names

  • MGC114275

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-23 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to interleukin-23 receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NK T cell activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NK T cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NK T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 17 cell lineage commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of T-helper 17 cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 17 type immune response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activation of JAK2 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of activation of JAK2 kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 
positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
positive regulation of granulocyte macrophage colony-stimulating factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-17 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of memory T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of memory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat4 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat4 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat5 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat5 protein ISO
Inferred from Sequence Orthology
more info
 
regulation of tyrosine phosphorylation of Stat1 protein IEA
Inferred from Electronic Annotation
more info
 
regulation of tyrosine phosphorylation of Stat1 protein ISO
Inferred from Sequence Orthology
more info
 
tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space ISO
Inferred from Sequence Orthology
more info
 
interleukin-23 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
interleukin-23 complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
interleukin-23 subunit alpha
Names
interleukin-23 subunit alpha
IL-23-A
IL-23p19
IL-23 subunit alpha
interleukin-23 subunit p19

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130410.2NP_569094.1  interleukin-23 subunit alpha precursor

    See proteins identical to NP_569094.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098907
    UniProtKB/Swiss-Prot
    Q91Z84
    Related
    ENSRNOP00000004363, ENSRNOT00000004363
    Conserved Domains (1) summary
    cl02473
    Location:69180
    IL6; Interleukin-6/G-CSF/MGF family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 

    Range
    2710609..2712723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000075.1 

    Range
    597260..599374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)