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Akap1 A kinase (PRKA) anchor protein 1 [ Mus musculus (house mouse) ]

Gene ID: 11640, updated on 20-Feb-2015
Official Symbol
Akap1provided by MGI
Official Full Name
A kinase (PRKA) anchor protein 1provided by MGI
Primary source
MGI:MGI:104729
See related
Ensembl:ENSMUSG00000018428; Vega:OTTMUSG00000001272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akap; AKAP84; C76494; C81186; DAKAP1; AKAP121; S-AKAP84
Orthologs
See Akap1 in MapViewer
Location:
11; 11 C
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (88830792..88864586, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 2 Neighboring gene RIKEN cDNA 0610039H22 gene Neighboring gene RIKEN cDNA C030037D09 gene Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene serine carboxypeptidase 1, opposite strand Neighboring gene serine carboxypeptidase 1 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex scaffold ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
negative regulation of NFAT protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lipid particle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
A-kinase anchor protein 1, mitochondrial
Names
A-kinase anchor protein 1, mitochondrial
D-AKAP-1
PRKA1
S-AKAP
a kinase anchor protein 1, mitochondrial
dual specificity A-kinase-anchoring protein 1
protein kinase A-anchoring protein 1
spermatid A-kinase anchor protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042541.1NP_001036006.1  A-kinase anchor protein 1, mitochondrial

    See proteins identical to NP_001036006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK020371, AK132749, AL596180, CJ167452
    Consensus CDS
    CCDS25229.1
    UniProtKB/Swiss-Prot
    O08715
    UniProtKB/TrEMBL
    Q9CTT7
    Related
    ENSMUSP00000018572, OTTMUSP00000001249, ENSMUST00000018572, OTTMUST00000002533
    Conserved Domains (3) summary
    cd04508
    Location:718763
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd00105
    Location:565625
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:661780
    TUDOR; Tudor domain
  2. NM_009648.2NP_033778.2  A-kinase anchor protein 1, mitochondrial

    See proteins identical to NP_033778.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK020371, AK132749, AL596180
    Consensus CDS
    CCDS25229.1
    UniProtKB/Swiss-Prot
    O08715
    UniProtKB/TrEMBL
    Q9CTT7
    Related
    ENSMUSP00000103536, OTTMUSP00000001248, ENSMUST00000107903, OTTMUST00000002532
    Conserved Domains (3) summary
    cd04508
    Location:718763
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd00105
    Location:565625
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:661780
    TUDOR; Tudor domain

RNA

  1. NR_104310.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK132749, AK186415, AW985969, BC065135

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    88830792..88864586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_879507.1 RNA Sequence

  2. XR_388330.1 RNA Sequence

Reference GRCm38.p3 NOD/ShiLtJ

Genomic

  1. NT_187003.1 Reference GRCm38.p3 NOD/ShiLtJ

    Range
    1976122..2009712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_885757.1 RNA Sequence

  2. XR_390026.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    98443444..98477088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)