Display Settings:

Format

Send to:

Choose Destination

HMGN1 high mobility group nucleosome binding domain 1 [ Homo sapiens (human) ]

Gene ID: 3150, updated on 7-Aug-2014
Official Symbol
HMGN1provided by HGNC
Official Full Name
high mobility group nucleosome binding domain 1provided by HGNC
Primary source
HGNC:4984
See related
Ensembl:ENSG00000205581; HPRD:01231; MIM:163920; Vega:OTTHUMG00000066178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMG14
Summary
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
See HMGN1 in Epigenomics, MapViewer
Location:
21q22.2
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 21 NC_000021.9 (39342315..39349121, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40714241..40721047, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene methyltransferase like 21A pseudogene 1 Neighboring gene BRWD1 antisense RNA 1 Neighboring gene ring finger protein (C3H2C3 type) 6 pseudogene 1 Neighboring gene tryptophan rich basic protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ27265, FLJ31471, MGC104230, MGC117425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
nucleosomal DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-templated transcription, elongation TAS
Traceable Author Statement
more info
PubMed 
post-embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pyrimidine dimer repair by nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
regulation of development, heterochronic IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
response to UV-B IEA
Inferred from Electronic Annotation
more info
 
response to UV-C IEA
Inferred from Electronic Annotation
more info
 
transcription-coupled nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
non-histone chromosomal protein HMG-14
Names
non-histone chromosomal protein HMG-14
nonhistone chromosomal protein HMG-14
high-mobility group nucleosome binding 1
high-mobility group nucleosome binding domain 1
high-mobility group (nonhistone chromosomal) protein 14
high mobility group nucleosome-binding domain-containing protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004965.6NP_004956.5  non-histone chromosomal protein HMG-14

    See proteins identical to NP_004956.5

    Status: REVIEWED

    Source sequence(s)
    AL582106, BC070154, BE779939
    Consensus CDS
    CCDS33559.1
    UniProtKB/Swiss-Prot
    P05114
    UniProtKB/TrEMBL
    Q6NSG7
    Related
    ENSP00000370125, OTTHUMP00000068966, ENST00000380749, OTTHUMT00000141645
    Conserved Domains (1) summary
    smart00527
    Location:292
    Blast Score: 139
    HMG17; domain in high mobilty group proteins HMG14 and HMG 17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000021.9 

    Range
    39342315..39349121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000153.1 

    Range
    26182661..26189471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 

    Range
    40275470..40282285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)