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Tsc1 tuberous sclerosis 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60445, updated on 10-Sep-2014
Official Symbol
Tsc1provided by RGD
Official Full Name
tuberous sclerosis 1provided by RGD
Primary source
RGD:620124
See related
Ensembl:ENSRNOG00000011470
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
See Tsc1 in MapViewer
Location:
3p12
Exon count:
26
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7219955..7269063)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (12570765..12619753)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC, polypeptide 5 Neighboring gene growth factor independent 1B transcription repressor Neighboring gene Rsb-66 protein Neighboring gene adenylate kinase 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of Rho GTPase activity IEA
Inferred from Electronic Annotation
more info
 
activation of Rho GTPase activity ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cell projection organization ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development ISO
Inferred from Sequence Orthology
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
kidney development ISO
Inferred from Sequence Orthology
more info
 
myelination IEA
Inferred from Electronic Annotation
more info
 
myelination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of translation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neural tube closure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
rRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
 
rRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of Ras GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of translation ISO
Inferred from Sequence Orthology
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
synapse organization IEA
Inferred from Electronic Annotation
more info
 
synapse organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
TSC1-TSC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
TSC1-TSC2 complex ISO
Inferred from Sequence Orthology
more info
 
actin filament IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hamartin
Names
hamartin
tuberous sclerosis 1 protein homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021854.1NP_068626.1  hamartin

    See proteins identical to NP_068626.1

    Status: PROVISIONAL

    Source sequence(s)
    AB011821
    UniProtKB/Swiss-Prot
    Q9Z136
    Related
    ENSRNOP00000016904, ENSRNOT00000016904
    Conserved Domains (3) summary
    pfam00261
    Location:779977
    Blast Score: 94
    Tropomyosin; Tropomyosin
    pfam04388
    Location:2719
    Blast Score: 1994
    Hamartin; Hamartin protein
    cl19113
    Location:758918
    Blast Score: 103
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 

    Range
    7219955..7269063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233843.2XP_006233905.1  

    See proteins identical to XP_006233905.1

    UniProtKB/Swiss-Prot
    Q9Z136
    Conserved Domains (3) summary
    pfam00261
    Location:779977
    Blast Score: 94
    Tropomyosin; Tropomyosin
    pfam04388
    Location:2719
    Blast Score: 1994
    Hamartin; Hamartin protein
    cl19113
    Location:758918
    Blast Score: 103
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. XM_006233849.2XP_006233911.1  

    Conserved Domains (3) summary
    pfam00261
    Location:774972
    Blast Score: 93
    Tropomyosin; Tropomyosin
    pfam04388
    Location:2714
    Blast Score: 1988
    Hamartin; Hamartin protein
    cl19113
    Location:753913
    Blast Score: 102
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. XM_006233844.2XP_006233906.1  

    See proteins identical to XP_006233906.1

    UniProtKB/Swiss-Prot
    Q9Z136
    Conserved Domains (3) summary
    pfam00261
    Location:779977
    Blast Score: 94
    Tropomyosin; Tropomyosin
    pfam04388
    Location:2719
    Blast Score: 1994
    Hamartin; Hamartin protein
    cl19113
    Location:758918
    Blast Score: 103
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  4. XM_006233845.2XP_006233907.1  

    See proteins identical to XP_006233907.1

    UniProtKB/Swiss-Prot
    Q9Z136
    Conserved Domains (3) summary
    pfam00261
    Location:779977
    Blast Score: 94
    Tropomyosin; Tropomyosin
    pfam04388
    Location:2719
    Blast Score: 1994
    Hamartin; Hamartin protein
    cl19113
    Location:758918
    Blast Score: 103
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  5. XM_006233847.2XP_006233909.1  

    See proteins identical to XP_006233909.1

    UniProtKB/Swiss-Prot
    Q9Z136
    Conserved Domains (3) summary
    pfam00261
    Location:779977
    Blast Score: 94
    Tropomyosin; Tropomyosin
    pfam04388
    Location:2719
    Blast Score: 1994
    Hamartin; Hamartin protein
    cl19113
    Location:758918
    Blast Score: 103
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  6. XM_006233846.2XP_006233908.1  

    See proteins identical to XP_006233908.1

    UniProtKB/Swiss-Prot
    Q9Z136
    Conserved Domains (3) summary
    pfam00261
    Location:779977
    Blast Score: 94
    Tropomyosin; Tropomyosin
    pfam04388
    Location:2719
    Blast Score: 1994
    Hamartin; Hamartin protein
    cl19113
    Location:758918
    Blast Score: 103
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate Rn_Celera

Genomic

  1. AC_000071.1 

    Range
    6767562..6795193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)