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    Flcn folliculin [ Mus musculus (house mouse) ]

    Gene ID: 216805, updated on 5-Dec-2015
    Official Symbol
    Flcnprovided by MGI
    Official Full Name
    folliculinprovided by MGI
    Primary source
    MGI:MGI:2442184
    See related
    Ensembl:ENSMUSG00000032633 Vega:OTTMUSG00000008092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bhd; FLCL; AU014660; B430214A04Rik
    Orthologs
    Location:
    11; 11 B1.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (59791408..59810039, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (59605252..59623275, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene myosin phosphatase Rho interacting protein Neighboring gene predicted gene, 34094 Neighboring gene phospholipase D family, member 6 Neighboring gene predicted gene 16062 Neighboring gene COP9 signalosome subunit 3 Neighboring gene 5',3'-nucleotidase, mitochondrial

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...

    Markers

    Homology

    Clone Names

    • MGC37841

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ATP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of angiogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation involved in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mitochondrial DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of post-translational protein modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of histone acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of pro-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with midbody ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271356.1NP_001258285.1  folliculin

      See identical proteins and their annotated locations for NP_001258285.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a protein. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL596204
      Consensus CDS
      CCDS24777.1
      UniProtKB/Swiss-Prot
      Q8QZS3
      Conserved Domains (1) summary
      pfam11704
      Location:104267
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    2. NM_001271357.1NP_001258286.1  folliculin

      See identical proteins and their annotated locations for NP_001258286.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK039106, AK136071, CJ052419
      Consensus CDS
      CCDS24777.1
      UniProtKB/Swiss-Prot
      Q8QZS3
      Related
      ENSMUSP00000091696, OTTMUSP00000030565, ENSMUST00000091246, OTTMUST00000062092
      Conserved Domains (1) summary
      pfam11704
      Location:104267
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    3. NM_146018.2NP_666130.1  folliculin

      See identical proteins and their annotated locations for NP_666130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK039106, AK080933, CJ059253
      Consensus CDS
      CCDS24777.1
      UniProtKB/Swiss-Prot
      Q8QZS3
      Related
      ENSMUSP00000099758, OTTMUSP00000008459, ENSMUST00000102697, OTTMUST00000018400
      Conserved Domains (1) summary
      pfam11704
      Location:104267
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport

    RNA

    1. NR_073164.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL596204
      Related
      ENSMUST00000148151

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

      Range
      59791408..59810039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248905.1XP_011247207.1  

      See identical proteins and their annotated locations for XP_011247207.1

      UniProtKB/Swiss-Prot
      Q8QZS3
      Conserved Domains (1) summary
      pfam11704
      Location:104267
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport

    RNA

    1. XR_879567.1 RNA Sequence