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    DISP1 dispatched homolog 1 (Drosophila) [ Homo sapiens (human) ]

    Gene ID: 84976, updated on 15-Jul-2015
    Official Symbol
    DISP1provided by HGNC
    Official Full Name
    dispatched homolog 1 (Drosophila)provided by HGNC
    Primary source
    HGNC:HGNC:19711
    See related
    Ensembl:ENSG00000154309; Ensembl:ENSG00000228106; HPRD:06326; MIM:607502; Vega:OTTHUMG00000037893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DISPA
    Summary
    The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
    Orthologs
    See DISP1 in Epigenomics, MapViewer
    Location:
    1q41
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (222814514..223005995)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222988342..223179337)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene axin interactor, dorsalization associated Neighboring gene uncharacterized LOC105372984 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene family with sequence similarity 177, member B Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 pseudogene 2 Neighboring gene uncharacterized LOC102724046 Neighboring gene toll-like receptor 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated (2012-07-06)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated (2012-07-06)

    ClinGen Genome Curation Page
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ43740, MGC13130, MGC16796, MGC104180, DKFZp434I0428

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hedgehog receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptide transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    diaphragm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    patched ligand maturation IEA
    Inferred from Electronic Annotation
    more info
     
    peptide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    smoothened signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    protein dispatched homolog 1
    Names
    dispatched A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009243.2 RefSeqGene

      Range
      5001..195907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032890.3NP_116279.2  protein dispatched homolog 1

      See identical proteins and their annotated locations for NP_116279.2

      Status: REVIEWED

      Source sequence(s)
      AC093152, BC007734, BC011542, DA756409
      Consensus CDS
      CCDS1536.1
      UniProtKB/Swiss-Prot
      Q96F81
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      222814514..223005995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510075.1XP_011508377.1  

      See identical proteins and their annotated locations for XP_011508377.1

      UniProtKB/Swiss-Prot
      Q96F81
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family
    2. XM_011510073.1XP_011508375.1  

      See identical proteins and their annotated locations for XP_011508375.1

      UniProtKB/Swiss-Prot
      Q96F81
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family
    3. XM_011510077.1XP_011508379.1  

      See identical proteins and their annotated locations for XP_011508379.1

      UniProtKB/Swiss-Prot
      Q96F81
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family
    4. XM_011510074.1XP_011508376.1  

      See identical proteins and their annotated locations for XP_011508376.1

      UniProtKB/Swiss-Prot
      Q96F81
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family
    5. XM_011510072.1XP_011508374.1  

      See identical proteins and their annotated locations for XP_011508374.1

      UniProtKB/Swiss-Prot
      Q96F81
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family
    6. XM_011510076.1XP_011508378.1  

      See identical proteins and their annotated locations for XP_011508378.1

      UniProtKB/Swiss-Prot
      Q96F81
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family
    7. XM_005273335.1XP_005273392.1  

      See identical proteins and their annotated locations for XP_005273392.1

      UniProtKB/Swiss-Prot
      Q96F81
      Related
      ENSP00000284476, OTTHUMP00000036011, ENST00000284476, OTTHUMT00000092512
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family
    8. XM_006711592.1XP_006711655.1  

      See identical proteins and their annotated locations for XP_006711655.1

      UniProtKB/Swiss-Prot
      Q96F81
      Conserved Domains (3) summary
      pfam02460
      Location:4561093
      Patched; Patched family
      pfam12533
      Location:54147
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
      cl21543
      Location:508671
      MMPL; MMPL family
    9. XM_006711594.2XP_006711657.1  

      See identical proteins and their annotated locations for XP_006711657.1

      Conserved Domains (2) summary
      pfam02460
      Location:262899
      Patched; Patched family
      cl21543
      Location:314477
      MMPL; MMPL family
    10. XM_011510078.1XP_011508380.1  

      See identical proteins and their annotated locations for XP_011508380.1

      Conserved Domains (2) summary
      pfam02460
      Location:262899
      Patched; Patched family
      cl21543
      Location:314477
      MMPL; MMPL family

    RNA

    1. XR_921983.1 RNA Sequence

    2. XR_921980.1 RNA Sequence

    3. XR_426911.2 RNA Sequence

    4. XR_426908.2 RNA Sequence

    5. XR_921986.1 RNA Sequence

    6. XR_921984.1 RNA Sequence

    7. XR_921985.1 RNA Sequence

    8. XR_921982.1 RNA Sequence

      Related
      ENST00000435378
    9. XR_921981.1 RNA Sequence

      Related
      ENST00000442171

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      224261462..224452463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)