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    FOLR3 folate receptor 3 (gamma) [ Homo sapiens (human) ]

    Gene ID: 2352, updated on 3-Apr-2016
    Official Symbol
    FOLR3provided by HGNC
    Official Full Name
    folate receptor 3 (gamma)provided by HGNC
    Primary source
    HGNC:HGNC:3795
    See related
    Ensembl:ENSG00000110203 HPRD:03918; MIM:602469; Vega:OTTHUMG00000167870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FR-G; FR-gamma; gamma-hFR
    Summary
    This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
    Orthologs
    Location:
    11q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (72135682..72139892)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71846771..71850934)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene anaphase promoting complex subunit 15 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 6 Neighboring gene folate receptor 1 (adult) pseudogene 1 Neighboring gene folate receptor 3 (gamma) pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    folic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    folic acid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032935.1 RefSeqGene

      Range
      4986..9168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000804.3NP_000795.2  folate receptor gamma isoform 1 precursor

      See identical proteins and their annotated locations for NP_000795.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC030285, CD368314, U08471
      Consensus CDS
      CCDS73344.1
      UniProtKB/Swiss-Prot
      P41439
      UniProtKB/TrEMBL
      A0A087WXL1
      Related
      ENSP00000481114, OTTHUMP00000276339, ENST00000611028, OTTHUMT00000396740
      Conserved Domains (1) summary
      pfam03024
      Location:36211
      Folate_rec; Folate receptor family
    2. NM_001318045.1NP_001304974.1  folate receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in its 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AP000812, BC030285, BI836723, CD368314, U08471
      UniProtKB/Swiss-Prot
      P41439
      Conserved Domains (1) summary
      pfam03024
      Location:1120
      Folate_rec; Folate receptor family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      72135682..72139892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544873.1XP_011543175.1  

      See identical proteins and their annotated locations for XP_011543175.1

      UniProtKB/TrEMBL
      A0A087WXL1
      Conserved Domains (1) summary
      pfam03024
      Location:36211
      Folate_rec; Folate receptor family
    2. XM_011544875.1XP_011543177.1  

      Conserved Domains (1) summary
      pfam03024
      Location:1120
      Folate_rec; Folate receptor family
    3. XM_011544874.1XP_011543176.1  

      See identical proteins and their annotated locations for XP_011543176.1

      UniProtKB/TrEMBL
      A0A087WXL1
      Conserved Domains (1) summary
      pfam03024
      Location:36211
      Folate_rec; Folate receptor family
    4. XM_011544876.1XP_011543178.1  

      Conserved Domains (1) summary
      pfam03024
      Location:30119
      Folate_rec; Folate receptor family

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      71730576..71734739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)