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RGS13 regulator of G-protein signaling 13 [ Homo sapiens (human) ]

Gene ID: 6003, updated on 11-Sep-2014
Official Symbol
RGS13provided by HGNC
Official Full Name
regulator of G-protein signaling 13provided by HGNC
Primary source
HGNC:HGNC:9995
Locus tag
RP11-92K2.1
See related
Ensembl:ENSG00000127074; HPRD:06222; MIM:607190; Vega:OTTHUMG00000035601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
See RGS13 in Epigenomics, MapViewer
Location:
1q31.2
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (192636138..192660311)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192605268..192629441)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 21 Neighboring gene regulator of G-protein signaling 1 Neighboring gene ribosomal protein S27a pseudogene 5 Neighboring gene microRNA 4426 Neighboring gene integrin beta 1 binding protein 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC17173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
termination of G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
regulator of G-protein signaling 13
Names
regulator of G-protein signaling 13
regulator of G-protein signalling 13

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002927.4NP_002918.1  regulator of G-protein signaling 13

    See proteins identical to NP_002918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    BC056866, BU942880
    Consensus CDS
    CCDS1376.1
    UniProtKB/TrEMBL
    A0A024R989
    UniProtKB/Swiss-Prot
    O14921
    Related
    ENSP00000375853, OTTHUMP00000033593, ENST00000391995, OTTHUMT00000086400
    Conserved Domains (1) summary
    cd08716
    Location:35148
    RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein
  2. NM_144766.2NP_658912.1  regulator of G-protein signaling 13

    See proteins identical to NP_658912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC016667, BC056866, BU942880
    Consensus CDS
    CCDS1376.1
    UniProtKB/TrEMBL
    A0A024R989
    UniProtKB/Swiss-Prot
    O14921
    Related
    ENSP00000442837, ENST00000543215
    Conserved Domains (1) summary
    cd08716
    Location:35148
    RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    192636138..192660311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    163841268..163865380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    194027097..194051266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)