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Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114700, updated on 10-Sep-2014
Official Symbol
Cyp27b1provided by RGD
Official Full Name
cytochrome P450, family 27, subfamily b, polypeptide 1provided by RGD
Primary source
RGD:69192
See related
Ensembl:ENSRNOG00000046214
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp40
Summary
cytochrome P450 enzyme that plays a role in vitamin D metabolism [RGD, Feb 2006]
See Cyp27b1 in MapViewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70333150..70340006)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (70512763..70517707)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene similar to C42C1.13 Neighboring gene methyltransferase like 1 Neighboring gene membrane-associated ring finger (C3HC4) 9 Neighboring gene cyclin-dependent kinase 4 Neighboring gene tetraspanin 31 Neighboring gene uncharacterized LOC103692874

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcidiol 1-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
calcidiol 1-monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
aging IDA
Inferred from Direct Assay
more info
PubMed 
bone mineralization ISO
Inferred from Sequence Orthology
more info
 
calcitriol biosynthetic process from calciol IDA
Inferred from Direct Assay
more info
PubMed 
calcitriol biosynthetic process from calciol IEA
Inferred from Electronic Annotation
more info
 
calcitriol biosynthetic process from calciol ISO
Inferred from Sequence Orthology
more info
 
calcitriol biosynthetic process from calciol TAS
Traceable Author Statement
more info
PubMed 
calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
decidualization ISO
Inferred from Sequence Orthology
more info
 
lactation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vitamin D 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vitamin D receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to copper ion IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to prostaglandin E IDA
Inferred from Direct Assay
more info
PubMed 
response to vitamin D IDA
Inferred from Direct Assay
more info
PubMed 
response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
vitamin D catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D catabolic process ISO
Inferred from Sequence Orthology
more info
 
vitamin D metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D metabolic process ISO
Inferred from Sequence Orthology
more info
 
vitamin D metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Names
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
P450C1 alpha
P450VD1-alpha
VD3 1A hydroxylase
cytochrome p450 27B1
cytochrome P450C1 alpha
cytochrome P450VD1-alpha
calcidiol 1-monooxygenase
25-OHD-1 alpha-hydroxylase
25-hydroxyvitamin D(3) 1-alpha-hydroxylase
cytochrome P450, subfamily 27b, polypeptide 1
cytochrome P450 subfamily XXVIIB polypeptide 1
cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1
NP_446215.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053763.1NP_446215.1  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

    See proteins identical to NP_446215.1

    Status: PROVISIONAL

    Source sequence(s)
    AB001992
    UniProtKB/Swiss-Prot
    O35132
    Related
    ENSRNOP00000064023, ENSRNOT00000072176
    Conserved Domains (1) summary
    pfam00067
    Location:34498
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 

    Range
    70333150..70340006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765374.1XP_008763596.1  

    See proteins identical to XP_008763596.1

    Conserved Domains (1) summary
    pfam00067
    Location:34498
    p450; Cytochrome P450

Alternate Rn_Celera

Genomic

  1. AC_000075.1 

    Range
    60014507..60019451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)