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PIGU phosphatidylinositol glycan anchor biosynthesis, class U [ Homo sapiens (human) ]

Gene ID: 128869, updated on 19-Jul-2014
Official Symbol
PIGUprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Uprovided by HGNC
Primary source
HGNC:15791
Locus tag
RP11-346K17.2
See related
Ensembl:ENSG00000101464; HPRD:12250; MIM:608528; Vega:OTTHUMG00000032304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAB1; CDC91L1
Summary
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]
See PIGU in Epigenomics, MapViewer
Location:
20q11.22
Exon count :
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (34560542..34677285, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33148346..33265089, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene dynein, light chain, roadblock-type 1 Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene nuclear receptor coactivator 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common sequence variants on 20q11.22 confer melanoma susceptibility.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GPI anchor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to GPI-anchor transamidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
C-terminal protein lipidation TAS
Traceable Author Statement
more info
 
GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
attachment of GPI anchor to protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
attachment of GPI anchor to protein TAS
Traceable Author Statement
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IC
Inferred by Curator
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phosphatidylinositol glycan anchor biosynthesis class U protein
Names
phosphatidylinositol glycan anchor biosynthesis class U protein
protein CDC91-like 1
GPI transamidase subunit
GPI transamidase component PIG-U
cell division cycle 91-like 1 protein
cell division cycle protein 91-like 1
CDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011497.1 

    Range
    5001..121744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080476.4NP_536724.1  phosphatidylinositol glycan anchor biosynthesis class U protein precursor

    See proteins identical to NP_536724.1

    Status: REVIEWED

    Source sequence(s)
    AY422169
    Consensus CDS
    CCDS13239.1
    UniProtKB/Swiss-Prot
    Q9H490
    Related
    ENSP00000217446, OTTHUMP00000030693, ENST00000217446, OTTHUMT00000078795
    Conserved Domains (1) summary
    pfam06728
    Location:20394
    Blast Score: 874
    PIG-U; GPI transamidase subunit PIG-U

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    34560542..34677285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    29928895..30044277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    33049160..33166522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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