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    Gapdh glyceraldehyde-3-phosphate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 14433, updated on 3-Jul-2016
    Official Symbol
    Gapdhprovided by MGI
    Official Full Name
    glyceraldehyde-3-phosphate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:95640
    See related
    Ensembl:ENSMUSG00000057666 Vega:OTTMUSG00000027118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gapd
    Summary
    This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014]
    Annotation information
    Note: GeneID 14433 was annotated on chromosome 6 on NCBI's Build 36.1 and GeneID 407972 (then associated with the functional Gapdh) was not annotated. Sequences associated with GeneID 14433 also align to chromosome 2 A3, the location of a highly related Gapdh pseudogene that was not annotated on Build 36.1. To connect the nomenclature with the annotation, GeneID 14433 was merged with GeneID 407972 and it now represents the functional Gapdh gene on chromosome 6. The RefSeq for Gapdh is NM_008084 with NM_001001303.1 being secondary to it. The Gapdh pseudogene on chromosome 2 is now represented by GeneID 100033452 and the RefSeq NG_005903.1. [13 Feb 2013]
    Orthologs
    Location:
    6 F2; 6 59.32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (125161721..125166467, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (125111870..125115601, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32616 Neighboring gene microRNA 7045 Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene NOP2 nucleolar protein Neighboring gene intermediate filament family orphan 1 Neighboring gene non-SMC condensin I complex, subunit D2 Neighboring gene small Cajal body-specific RNA 10 Neighboring gene mitochondrial ribosomal protein L51

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC102544, MGC102546, MGC103190, MGC103191, MGC105239

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-cysteine S-nitrosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-cysteine S-trans-nitrosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    response to ammonium ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    GAIT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GAIT complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    lipid particle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glyceraldehyde-3-phosphate dehydrogenase
    Names
    peptidyl-cysteine S-nitrosylase GAPDH
    NP_001276655.1
    NP_032110.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289726.1NP_001276655.1  glyceraldehyde-3-phosphate dehydrogenase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC166162, AK140794, GU214026
      Consensus CDS
      CCDS80613.1
      UniProtKB/Swiss-Prot
      P16858
      UniProtKB/TrEMBL
      A0A0A0MQF6, D2KHZ9
      Related
      ENSMUSP00000113942, OTTMUSP00000033702, ENSMUST00000117757, OTTMUST00000067086
      Conserved Domains (3) summary
      smart00846
      Location:28176
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      COG0057
      Location:27359
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam02800
      Location:181338
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
    2. NM_008084.3NP_032110.1  glyceraldehyde-3-phosphate dehydrogenase isoform 2

      See identical proteins and their annotated locations for NP_032110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK140794, CJ155387, GU214026
      Consensus CDS
      CCDS51913.1
      UniProtKB/Swiss-Prot
      P16858
      UniProtKB/TrEMBL
      D2KHZ9
      Related
      ENSMUSP00000113213, OTTMUSP00000033701, ENSMUST00000118875, OTTMUST00000067084
      Conserved Domains (3) summary
      smart00846
      Location:2150
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      COG0057
      Location:1333
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam02800
      Location:155312
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      125161721..125166467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321385.1XP_017176874.1