Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Il6 interleukin 6 [ Mus musculus (house mouse) ]

    Gene ID: 16193, updated on 5-Jul-2015
    Official Symbol
    Il6provided by MGI
    Official Full Name
    interleukin 6provided by MGI
    Primary source
    MGI:MGI:96559
    See related
    Ensembl:ENSMUSG00000025746; Vega:OTTMUSG00000054480
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il-6
    Orthologs
    Location:
    5 B1; 5 15.7 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (30013161..30019968)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30339701..30346508)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 10 pseudogene Neighboring gene vacuole membrane protein 1 pseudogene Neighboring gene RIKEN cDNA A230098N10 gene Neighboring gene uncharacterized LOC102640315 Neighboring gene thymidylate synthase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-6 receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-6 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to interleukin-6 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    T-helper 17 cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in salivary gland morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-1 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell proliferation involved in salivary gland morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucagon secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hepatic immune response ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-6-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    myeloid cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chemokine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of chemokine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of muscle organ development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T-helper 2 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of immunoglobulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of Stat3 protein ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-6 receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interleukin-6
    Names
    B-cell hybridoma growth factor
    interleukin HP-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031168.1NP_112445.1  interleukin-6 precursor

      See identical proteins and their annotated locations for NP_112445.1

      Status: PROVISIONAL

      Source sequence(s)
      X54542
      Consensus CDS
      CCDS19153.1
      UniProtKB/TrEMBL
      A2RTD1
      UniProtKB/Swiss-Prot
      P08505
      Related
      ENSMUSP00000026845, OTTMUSP00000071554, ENSMUST00000026845, OTTMUST00000135092
      Conserved Domains (1) summary
      pfam00489
      Location:55209
      IL6; Interleukin-6/G-CSF/MGF family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      30013161..30019968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      27530266..27537070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)