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    egf epidermal growth factor [ Danio rerio (zebrafish) ]

    Gene ID: 403045, updated on 16-Jan-2016
    Official Symbol
    egfprovided by ZNC
    Official Full Name
    epidermal growth factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070922-1
    See related
    Ensembl:ENSDARG00000052739; Vega:OTTDARG00000028045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Orthologs
    See egf in MapViewer
    Location:
    chromosome: 14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    104 current GRCz10 (GCF_000002035.5) 14 NC_007125.6 (35939512..35985425, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 14 NC_007125.5 (37499208..37546191, complement)

    Chromosome 14 - NC_007125.6Genomic Context describing neighboring genes Neighboring gene paired-like homeodomain 2 Neighboring gene ELOVL fatty acid elongase 6 Neighboring gene info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a Neighboring gene glycoprotein M6Aa

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    Wnt-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway involved in dorsal/ventral axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    pro-epidermal growth factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205731.1NP_991294.1  pro-epidermal growth factor

      See identical proteins and their annotated locations for NP_991294.1

      Status: PROVISIONAL

      Source sequence(s)
      AY332224
      UniProtKB/TrEMBL
      Q6VQA2
      Related
      ENSDARP00000069126, OTTDARP00000030455, ENSDART00000074639, OTTDART00000037999
      Conserved Domains (5) summary
      PHA03099
      Location:896995
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00135
      Location:571613
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00054
      Location:840875
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:378413
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:288331
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz10 Primary Assembly

    Genomic

    1. NC_007125.6 Reference GRCz10 Primary Assembly

      Range
      35939512..35985425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291103.1XP_009289378.1  

      Conserved Domains (7) summary
      PHA03099
      Location:9581057
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00135
      Location:634676
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00054
      Location:903938
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:441476
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cd05819
      Location:4777
      NHL; NHL repeat [structural motif]
      cl00057
      Location:351394
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl18310
      Location:34197
      NHL; NHL repeat unit of beta-propeller proteins
    2. XM_005157314.2XP_005157371.1  

      UniProtKB/TrEMBL
      F1QGQ2
      Related
      ENSDARP00000111809, ENSDART00000126178
      Conserved Domains (7) summary
      PHA03099
      Location:9591058
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00135
      Location:634676
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00054
      Location:903938
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:441476
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cd05819
      Location:4777
      NHL; NHL repeat [structural motif]
      cl00057
      Location:351394
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl18310
      Location:34197
      NHL; NHL repeat unit of beta-propeller proteins