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CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 [ Homo sapiens (human) ]

Gene ID: 126410, updated on 11-Sep-2014
Official Symbol
CYP4F22provided by HGNC
Official Full Name
cytochrome P450, family 4, subfamily F, polypeptide 22provided by HGNC
Primary source
See related
Ensembl:ENSG00000171954; HPRD:08256; MIM:611495; Vega:OTTHUMG00000182451
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
See CYP4F22 in Epigenomics, MapViewer
Exon count:
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (15508525..15552317)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15619336..15663128)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RAS protein activator like 3 Neighboring gene peptidoglycan recognition protein 2 Neighboring gene staufen double-stranded RNA binding protein 1 pseudogene Neighboring gene cytochrome P450, family 4, subfamily F, polypeptide 23, pseudogene Neighboring gene ribosomal protein L23a pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytochrome P450 - arranged by substrate type, organism-specific biosystem (from REACTOME)
    Cytochrome P450 - arranged by substrate type, organism-specific biosystemThe P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate s...
  • Eicosanoids, organism-specific biosystem (from REACTOME)
    Eicosanoids, organism-specific biosystemArachidonic acid is metabolized via three major enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P450. The cytochrome P450 pathway metabolites are oxygenated metabolites of arachidoni...
  • Fatty acids, organism-specific biosystem (from REACTOME)
    Fatty acids, organism-specific biosystemThe CYP4 family are the main CYPs involved in the metabolism of long-chain fatty acids.
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Miscellaneous substrates, organism-specific biosystem (from REACTOME)
    Miscellaneous substrates, organism-specific biosystemApproximately a quarter of the 57 human CYPs still remain "orphans" in the sense that their function, expression sites, and regulation are largely not elucidated. While there is enough experimental e...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • cytochrome P450, organism-specific biosystem (from WikiPathways)
    cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
  • metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    metapathway biotransformation, organism-specific biosystem
    metapathway biotransformation
Products Interactant Other Gene Complex Source Pubs Description



Clone Names

  • FLJ39501

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
iron ion binding IEA
Inferred from Electronic Annotation
more info
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
Preferred Names
cytochrome P450 4F22
cytochrome P450 4F22
cytochrome P450, family 2, subfamily E, polypeptide 2 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_007987.1 

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173483.3NP_775754.2  cytochrome P450 4F22

    See proteins identical to NP_775754.2

    Status: REVIEWED

    Source sequence(s)
    AC011492, AI341068, BC069351, DA874258
    Consensus CDS
    ENSP00000269703, OTTHUMP00000269342, ENST00000269703, OTTHUMT00000461338
    Conserved Domains (1) summary
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly


  1. NC_000019.10 

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef


  1. AC_000151.1 

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1


  1. NC_018930.2 

    GenBank, FASTA, Sequence Viewer (Graphics)