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MIF4GD MIF4G domain containing [ Homo sapiens (human) ]

Gene ID: 57409, updated on 11-Sep-2014
Official Symbol
MIF4GDprovided by HGNC
Official Full Name
MIF4G domain containingprovided by HGNC
Primary source
HGNC:HGNC:24030
See related
Ensembl:ENSG00000125457; HPRD:10629; MIM:612072; Vega:OTTHUMG00000179485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIFD; AD023; SLIP1
Summary
This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
See MIF4GD in Epigenomics, MapViewer
Location:
17q25.1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (75266228..75271292, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73262309..73267373, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nucleoporin 85kDa Neighboring gene golgi-associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene uncharacterized LOC100287042 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Neighboring gene growth factor receptor-bound protein 2 Neighboring gene ribosomal protein L36a pseudogene 7

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC45027

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
Preferred Names
MIF4G domain-containing protein
Names
MIF4G domain-containing protein
SLBP-interacting protein 1
SLBP (stem loop binding protein)-interacting protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242498.1NP_001229427.1  MIF4G domain-containing protein isoform 1

    See proteins identical to NP_001229427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC022211, AK300711, BC033759, BI752882
    Consensus CDS
    CCDS58598.1
    UniProtKB/Swiss-Prot
    A9UHW6
    Related
    ENSP00000462459, OTTHUMP00000261607, ENST00000579297, OTTHUMT00000446673
    Conserved Domains (1) summary
    cl02652
    Location:75220
    MIF4G; MIF4G domain
  2. NM_001242500.1NP_001229429.1  MIF4G domain-containing protein isoform 2

    See proteins identical to NP_001229429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AC022211, BC033759, BU190758
    Consensus CDS
    CCDS11719.1
    UniProtKB/Swiss-Prot
    A9UHW6
    Conserved Domains (1) summary
    cl02652
    Location:68213
    MIF4G; MIF4G domain
  3. NM_001242501.1NP_001229430.1  MIF4G domain-containing protein isoform 4

    See proteins identical to NP_001229430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    BC033759, CA488406
    Consensus CDS
    CCDS56044.1
    UniProtKB/Swiss-Prot
    A9UHW6
    Related
    ENSP00000484245, ENST00000618645
    Conserved Domains (1) summary
    cl02652
    Location:8179
    MIF4G; MIF4G domain
  4. NM_020679.3NP_065730.2  MIF4G domain-containing protein isoform 2

    See proteins identical to NP_065730.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AC022211, BC033759, BI752882, BX404175
    Consensus CDS
    CCDS11719.1
    UniProtKB/Swiss-Prot
    A9UHW6
    Related
    ENSP00000245551, OTTHUMP00000261606, ENST00000245551, OTTHUMT00000446672
    Conserved Domains (1) summary
    cl02652
    Location:68213
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    75266228..75271292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257532.2XP_005257589.1  

    See proteins identical to XP_005257589.1

    UniProtKB/Swiss-Prot
    A9UHW6
    Related
    ENSP00000321625, OTTHUMP00000261605, ENST00000325102, OTTHUMT00000446671
    Conserved Domains (1) summary
    cl02652
    Location:8179
    MIF4G; MIF4G domain
  2. XM_005257530.1XP_005257587.1  

    See proteins identical to XP_005257587.1

    UniProtKB/Swiss-Prot
    A9UHW6
    Related
    ENSP00000463334, OTTHUMP00000261608, ENST00000577542, OTTHUMT00000446674
    Conserved Domains (1) summary
    cl02652
    Location:75220
    MIF4G; MIF4G domain
  3. XM_005257533.1XP_005257590.1  

    See proteins identical to XP_005257590.1

    UniProtKB/Swiss-Prot
    A9UHW6
    Conserved Domains (1) summary
    cl02652
    Location:8179
    MIF4G; MIF4G domain
  4. XM_006721985.1XP_006722048.1  

    See proteins identical to XP_006722048.1

    UniProtKB/Swiss-Prot
    A9UHW6
    Conserved Domains (1) summary
    cl02652
    Location:75220
    MIF4G; MIF4G domain
  5. XM_006721986.1XP_006722049.1  

    See proteins identical to XP_006722049.1

    UniProtKB/Swiss-Prot
    A9UHW6
    Conserved Domains (1) summary
    cl02652
    Location:75220
    MIF4G; MIF4G domain
  6. XM_005257531.2XP_005257588.1  

    See proteins identical to XP_005257588.1

    UniProtKB/Swiss-Prot
    A9UHW6
    Conserved Domains (1) summary
    cl02652
    Location:8179
    MIF4G; MIF4G domain

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    68672503..68677577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    73326890..73331970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)