Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 55294, updated on 23-Aug-2015
    Official Symbol
    FBXW7provided by HGNC
    Official Full Name
    F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:16712
    See related
    Ensembl:ENSG00000109670; HPRD:05888; MIM:606278; Vega:OTTHUMG00000185246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
    Orthologs
    See FBXW7 in Epigenomics, MapViewer
    Location:
    4q31.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (152321258..152536095, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (153242410..153456393, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377492 Neighboring gene uncharacterized LOC105377491 Neighboring gene dual endothelin-1(VEGFsp)/angiotensin II receptor pseudogene Neighboring gene microRNA 3140 Neighboring gene uncharacterized protein DKFZP434I0714 Neighboring gene uncharacterized LOC105377493 Neighboring gene microRNA 4453 Neighboring gene ribosomal protein S3a pseudogene 18

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem (from REACTOME)
      Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystemTRiC has broad recognition specificities, but in the cell it interacts with only a defined set of substrates (Yam et al. 2008). Many of its substrates that are targeted during biosynthesis are conse...
    • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
      Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
    • Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystemFBXW7 (FBW7) is a component of the SCF (SKP1, CUL1, and F-box protein) ubiquitin ligase complex SCF-FBW7 which is involved in the degradation of NOTCH1 (Oberg et al. 2001, Wu et al. 2001, Fryer et al...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling, organism-specific biosystem (from REACTOME)
      Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling, organism-specific biosystemLoss of function mutations found in FBXW7 in T-cell acute lymphoblastic leukemia are predominantly dominant negative missense mutations that target one of the three highly conserved arginine residues...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystem (from WikiPathways)
      Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystemThis pathway describes the Parkin-Ubiquitin proteasome degradation system.
    • Protein folding, organism-specific biosystem (from REACTOME)
      Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
    • SCF-FBW7 complex, organism-specific biosystem (from KEGG)
      SCF-FBW7 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBW7 complex, conserved biosystem (from KEGG)
      SCF-FBW7 complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
    • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
    • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ16457, DKFZp686F23254

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cyclin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Notch signaling pathway TAS
    Traceable Author Statement
    more info
     
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of SREBP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of hepatocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epidermal growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of proteasomal protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell cycle G1/S phase transition TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculature development TAS
    Traceable Author Statement
    more info
    PubMed 
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    F-box/WD repeat-containing protein 7
    Names
    F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
    F-box protein FBW7
    F-box protein FBX30
    F-box protein SEL-10
    archipelago
    homolog of C elegans sel-10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029466.1 RefSeqGene

      Range
      4780..218763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001013415.1NP_001013433.1  F-box/WD repeat-containing protein 7 isoform 3

      See identical proteins and their annotated locations for NP_001013433.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC080078, AY049984, BX498391
      Consensus CDS
      CCDS34078.1
      UniProtKB/Swiss-Prot
      Q969H0
      Related
      ENSP00000296555, OTTHUMP00000273139, ENST00000296555, OTTHUMT00000469957
      Conserved Domains (3) summary
      COG2319
      Location:249589
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:256532
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:163207
      F-box-like; F-box-like
    2. NM_001257069.1NP_001243998.1  F-box/WD repeat-containing protein 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC014503, HQ873866
      Consensus CDS
      CCDS64082.1
      UniProtKB/TrEMBL
      G0Z2K0
      UniProtKB/TrEMBL
      S4R3U4
      Related
      ENSP00000474751, OTTHUMP00000273144, ENST00000604872, OTTHUMT00000469967
    3. NM_018315.4NP_060785.2  F-box/WD repeat-containing protein 7 isoform 2

      See identical proteins and their annotated locations for NP_060785.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC080078, AF411972, BI496455, DA321362
      Consensus CDS
      CCDS3778.1
      UniProtKB/Swiss-Prot
      Q969H0
      Related
      ENSP00000263981, OTTHUMP00000273140, ENST00000263981, OTTHUMT00000469958
      Conserved Domains (3) summary
      COG2319
      Location:287627
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:294570
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:201245
      F-box-like; F-box-like
    4. NM_033632.3NP_361014.1  F-box/WD repeat-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_361014.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC023424, AC080078, AI598129, BC117244
      Consensus CDS
      CCDS3777.1
      UniProtKB/Swiss-Prot
      Q969H0
      Conserved Domains (3) summary
      COG2319
      Location:369692
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:374650
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:281325
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      152321258..152536095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532088.1XP_011530390.1  

      See identical proteins and their annotated locations for XP_011530390.1

      Conserved Domains (3) summary
      COG2319
      Location:200540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:207483
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:114158
      F-box-like; F-box-like
    2. XM_011532085.1XP_011530387.1  

      See identical proteins and their annotated locations for XP_011530387.1

      UniProtKB/Swiss-Prot
      Q969H0
      Related
      ENSP00000281708, OTTHUMP00000273138, ENST00000281708, OTTHUMT00000469956
      Conserved Domains (3) summary
      COG2319
      Location:369692
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:374650
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:281325
      F-box-like; F-box-like
    3. XM_011532084.1XP_011530386.1  

      See identical proteins and their annotated locations for XP_011530386.1

      UniProtKB/Swiss-Prot
      Q969H0
      Conserved Domains (3) summary
      COG2319
      Location:369692
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:374650
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:281325
      F-box-like; F-box-like
    4. XM_011532087.1XP_011530389.1  

      See identical proteins and their annotated locations for XP_011530389.1

      Conserved Domains (3) summary
      COG2319
      Location:339679
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:346622
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:253297
      F-box-like; F-box-like
    5. XM_011532083.1XP_011530385.1  

      See identical proteins and their annotated locations for XP_011530385.1

      UniProtKB/Swiss-Prot
      Q969H0
      Conserved Domains (3) summary
      COG2319
      Location:369692
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:374650
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:281325
      F-box-like; F-box-like
    6. XM_011532086.1XP_011530388.1  

      See identical proteins and their annotated locations for XP_011530388.1

      Conserved Domains (3) summary
      COG2319
      Location:339679
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:346622
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:253297
      F-box-like; F-box-like

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      153220162..153434185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)