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Per1 period circadian clock 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287422, updated on 19-Jul-2014
Official Symbol
Per1provided by RGD
Official Full Name
period circadian clock 1provided by RGD
Primary source
RGD:727863
See related
Ensembl:ENSRNOG00000007387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
rper1
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. [provided by RefSeq, Jan 2014]
See Per1 in MapViewer
Location:
10q24
Exon count:
24
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (55424863..55439853)

Chromosome 10 - NC_005109.3Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L10a-like Neighboring gene vesicle-associated membrane protein 2 Neighboring gene transfer RNA serine (anticodon CGA) Neighboring gene hes family bHLH transcription factor 7 Neighboring gene transfer RNA arginine (anticodon UCU)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian rhythm, organism-specific biosystem (from KEGG)
    Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Circadian rhythm, conserved biosystem (from KEGG)
    Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
    Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC112772

Gene Ontology Provided by RGD

Function Evidence Code Pubs
E-box binding IEA
Inferred from Electronic Annotation
more info
 
E-box binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian regulation of translation ISO
Inferred from Sequence Orthology
more info
 
circadian regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
entrainment of circadian clock by photoperiod ISO
Inferred from Sequence Orthology
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3 acetylation ISO
Inferred from Sequence Orthology
more info
 
histone H3 deacetylation ISO
Inferred from Sequence Orthology
more info
 
histone H3 deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucocorticoid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
posttranscriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
posttranscriptional regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 
regulation of hair cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of hair cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 
regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
period circadian protein homolog 1
Names
period circadian protein homolog 1
period 1
period homolog 1
circadian clock protein PERIOD 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034125.1NP_001029297.1  period circadian protein homolog 1

    See proteins identical to NP_001029297.1

    Status: PROVISIONAL

    Source sequence(s)
    AY903229
    UniProtKB/Swiss-Prot
    Q8CHI5
    Related
    ENSRNOP00000053964, ENSRNOT00000057136
    Conserved Domains (3) summary
    cd00130
    Location:360461
    Blast Score: 140
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:10791227
    Blast Score: 521
    Period_C; Period protein 2/3C-terminal region
    pfam14598
    Location:360461
    Blast Score: 154
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005109.3 

    Range
    55424863..55439853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246613.1XP_006246675.1  

    See proteins identical to XP_006246675.1

    UniProtKB/Swiss-Prot
    Q8CHI5
    Conserved Domains (3) summary
    cd00130
    Location:360461
    Blast Score: 140
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:10791227
    Blast Score: 521
    Period_C; Period protein 2/3C-terminal region
    pfam14598
    Location:360461
    Blast Score: 154
    PAS_11; PAS domain
  2. XM_006246614.1XP_006246676.1  

    See proteins identical to XP_006246676.1

    UniProtKB/Swiss-Prot
    Q8CHI5
    Conserved Domains (3) summary
    cd00130
    Location:360461
    Blast Score: 140
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:10791227
    Blast Score: 521
    Period_C; Period protein 2/3C-terminal region
    pfam14598
    Location:360461
    Blast Score: 154
    PAS_11; PAS domain

Alternate Rn_Celera

Genomic

  1. AC_000078.1 

    Range
    52971073..52979969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)