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CTDNEP1 CTD nuclear envelope phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 23399, updated on 5-Apr-2015
Official Symbol
CTDNEP1provided by HGNC
Official Full Name
CTD nuclear envelope phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:19085
See related
Ensembl:ENSG00000175826; HPRD:16845; MIM:610684; Vega:OTTHUMG00000102180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET56; DULLARD; HSA011916
Orthologs
See CTDNEP1 in MapViewer
Location:
17p13
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (7243587..7251940, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7146906..7155259, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 23 Neighboring gene GABA(A) receptor-associated protein Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene claudin 7 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Depolymerisation of the Nuclear Lamina, organism-specific biosystem (from REACTOME)
    Depolymerisation of the Nuclear Lamina, organism-specific biosystemThe nuclear envelope breakdown in mitotic prophase involves depolymerisation of lamin filaments, the main constituents of the nuclear lamina. The nuclear lamina is located at the nuclear face of the ...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Prophase, organism-specific biosystem (from REACTOME)
    Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
  • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
    Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
gamete generation IEA
Inferred from Electronic Annotation
more info
 
mesoderm development IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
nuclear envelope organization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of triglyceride biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Nem1-Spo7 phosphatase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CTD nuclear envelope phosphatase 1
Names
CTD nuclear envelope phosphatase 1
C-terminal domain nuclear envelope phosphatase 1
dullard homolog
serine/threonine-protein phosphatase dullard
NP_001137247.1
NP_056158.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143775.1NP_001137247.1  CTD nuclear envelope phosphatase 1

    See identical proteins and their annotated locations for NP_001137247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC003688, AC120057, BC009295
    Consensus CDS
    CCDS11093.1
    UniProtKB/Swiss-Prot
    O95476
    Related
    ENSP00000460683, OTTHUMP00000128375, ENST00000574322, OTTHUMT00000220030
    Conserved Domains (1) summary
    TIGR02251
    Location:61229
    protein_phosphatase_putative; Dullard-like phosphatase domain
  2. NM_015343.4NP_056158.2  CTD nuclear envelope phosphatase 1

    See identical proteins and their annotated locations for NP_056158.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC003688, AC120057, BC009295
    Consensus CDS
    CCDS11093.1
    UniProtKB/Swiss-Prot
    O95476
    Related
    ENSP00000321732, OTTHUMP00000258327, ENST00000318988, OTTHUMT00000440216
    Conserved Domains (1) summary
    TIGR02251
    Location:61229
    protein_phosphatase_putative; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    7243587..7251940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    7155699..7164051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)