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    OPRPN opiorphin prepropeptide [ Homo sapiens (human) ]

    Gene ID: 58503, updated on 11-Mar-2016
    Official Symbol
    OPRPNprovided by HGNC
    Official Full Name
    opiorphin prepropeptideprovided by HGNC
    Primary source
    HGNC:HGNC:17279
    See related
    Ensembl:ENSG00000171199 HPRD:16408; MIM:608936; Vega:OTTHUMG00000160845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BPLP; PRL1; PROL1; opiorphin
    Summary
    This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Orthologs
    Location:
    4q13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (70397882..70410197)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71263599..71275914)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene submaxillary gland androgen regulated protein 3A Neighboring gene submaxillary gland androgen regulated protein 3B Neighboring gene mucin 7, secreted Neighboring gene amelotin

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retina homeostasis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    proline-rich protein 1
    Names
    basic proline-rich lacrimal protein
    basic proline-rich protein
    proline rich, lacrimal 1
    proline-rich 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302807.1NP_001289736.1  proline-rich protein 1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (2) lacks the functional QRFSR pentapeptide, known as opiorphin, located in the N-terminal of isoform 1.
      Source sequence(s)
      CD721906, CD722615, CD723077, CD723628
      Conserved Domains (1) summary
      pfam15621
      Location:119
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family
    2. NM_021225.4NP_067048.4  proline-rich protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_067048.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC092438, CD722615, CK430664
      Consensus CDS
      CCDS43235.1
      UniProtKB/Swiss-Prot
      Q99935
      Related
      ENSP00000382485, OTTHUMP00000219147, ENST00000399575, OTTHUMT00000362639
      Conserved Domains (1) summary
      pfam15621
      Location:3103
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

    RNA

    1. NR_126503.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      CD721906, CD722615, CD723628, CK429697

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      70397882..70410197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      71299691..71312010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)