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Rhbdd3 rhomboid domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 279766, updated on 24-Jan-2015
Official Symbol
Rhbdd3provided by MGI
Official Full Name
rhomboid domain containing 3provided by MGI
Primary source
MGI:MGI:2444684
Locus tag
RP23-338J18.2
See related
Ensembl:ENSMUSG00000034175; Vega:OTTMUSG00000005080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptag
Orthologs
See Rhbdd3 in MapViewer
Location:
11 A1; 11
Exon count:
11
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (5099271..5106098)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A Neighboring gene Ewing sarcoma breakpoint region 1 Neighboring gene predicted gene, 35377 Neighboring gene EMI domain containing 1 Neighboring gene predicted gene, 35459

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • 5730411O18Rik, RP23-338J18.2

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rhomboid domain-containing protein 3
Names
rhomboid domain-containing protein 3
pituitary-derived proapoptotic

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290491.1NP_001277420.1  rhomboid domain-containing protein 3 isoform b

    See proteins identical to NP_001277420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses two alternate splice sites in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AK053223, AL645845, BB841991, BY641428
    Consensus CDS
    CCDS70133.1
    UniProtKB/Swiss-Prot
    Q8BP97
    Conserved Domains (1) summary
    cl21463
    Location:316359
    UBA_like_SF; UBA domain-like superfamily
  2. NM_001290492.1NP_001277421.1  rhomboid domain-containing protein 3 isoform a

    See proteins identical to NP_001277421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AK077457, AL645845, BB841991, BC145287, BY641428
    Consensus CDS
    CCDS24397.1
    UniProtKB/TrEMBL
    B7ZNJ8
    UniProtKB/Swiss-Prot
    Q8BP97
    Conserved Domains (1) summary
    cl21463
    Location:326369
    UBA_like_SF; UBA domain-like superfamily
  3. NM_001290493.1NP_001277422.1  rhomboid domain-containing protein 3 isoform a

    See proteins identical to NP_001277422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK077457, AL645845, BY641428
    Consensus CDS
    CCDS24397.1
    UniProtKB/TrEMBL
    B7ZNJ8
    UniProtKB/Swiss-Prot
    Q8BP97
    Conserved Domains (1) summary
    cl21463
    Location:326369
    UBA_like_SF; UBA domain-like superfamily
  4. NM_177370.4NP_796344.1  rhomboid domain-containing protein 3 isoform a

    See proteins identical to NP_796344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK077457, AL645845, BB841991, BY641428
    Consensus CDS
    CCDS24397.1
    UniProtKB/TrEMBL
    B7ZNJ8
    UniProtKB/Swiss-Prot
    Q8BP97
    Conserved Domains (1) summary
    cl21463
    Location:326369
    UBA_like_SF; UBA domain-like superfamily

RNA

  1. NR_110961.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a 5' exon, and uses two alternate splice sites at internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK053223, AK077457, BY641428

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    5099271..5106098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514715.1XP_006514778.1  

    See proteins identical to XP_006514778.1

    UniProtKB/TrEMBL
    B7ZNJ8
    UniProtKB/Swiss-Prot
    Q8BP97
    Conserved Domains (1) summary
    cl21463
    Location:326369
    UBA_like_SF; UBA domain-like superfamily
  2. XM_006514713.1XP_006514776.1  

    Conserved Domains (1) summary
    cl21463
    Location:326369
    UBA_like_SF; UBA domain-like superfamily
  3. XM_006514717.1XP_006514780.1  

    Related
    ENSMUSP00000044703, OTTMUSP00000005291, ENSMUST00000036320, OTTMUST00000011354
    Conserved Domains (1) summary
    cl21463
    Location:316359
    UBA_like_SF; UBA domain-like superfamily
  4. XM_006514714.1XP_006514777.1  

    See proteins identical to XP_006514777.1

    UniProtKB/TrEMBL
    B7ZNJ8
    UniProtKB/Swiss-Prot
    Q8BP97
    Conserved Domains (1) summary
    cl21463
    Location:326369
    UBA_like_SF; UBA domain-like superfamily
  5. XM_006514716.1XP_006514779.1  

    Related
    ENSMUSP00000105504, ENSMUST00000109878
    Conserved Domains (1) summary
    cl21463
    Location:326369
    UBA_like_SF; UBA domain-like superfamily

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    5596534..5603187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)