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Bmpr1a bone morphogenetic protein receptor, type IA [ Rattus norvegicus (Norway rat) ]

Gene ID: 81507, updated on 8-Feb-2015
Official Symbol
Bmpr1aprovided by RGD
Official Full Name
bone morphogenetic protein receptor, type IAprovided by RGD
Primary source
RGD:70989
See related
Ensembl:ENSRNOG00000010814
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
may act as a serine/threonine kinase receptor; may mediate bone morphogenetic protein-induced bone formation [RGD, Feb 2006]
Orthologs
See Bmpr1a in MapViewer
Location:
16p16
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (10758526..10802512, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (9084569..9127943, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene synuclein, gamma Neighboring gene multimerin 2 Neighboring gene uncharacterized LOC100912503 Neighboring gene LIM domain binding 3 Neighboring gene opsin 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding IEA
Inferred from Electronic Annotation
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor signaling protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding RNA polymerase II transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding RNA polymerase II transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Mullerian duct regression IEA
Inferred from Electronic Annotation
more info
 
Mullerian duct regression ISO
Inferred from Sequence Orthology
more info
 
anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
biological_process ND
No biological Data available
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cartilage development ISO
Inferred from Sequence Orthology
more info
 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
developmental growth IEA
Inferred from Electronic Annotation
more info
 
developmental growth ISO
Inferred from Sequence Orthology
more info
 
dorsal/ventral axis specification IEA
Inferred from Electronic Annotation
more info
 
dorsal/ventral axis specification ISO
Inferred from Sequence Orthology
more info
 
dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
 
ectoderm development IEA
Inferred from Electronic Annotation
more info
 
ectoderm development ISO
Inferred from Sequence Orthology
more info
 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic organ development IEA
Inferred from Electronic Annotation
more info
 
embryonic organ development ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion formation IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
endoderm development ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
heart formation IEA
Inferred from Electronic Annotation
more info
 
heart formation ISO
Inferred from Sequence Orthology
more info
 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
immune response ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
lateral mesoderm development IEA
Inferred from Electronic Annotation
more info
 
lateral mesoderm development ISO
Inferred from Sequence Orthology
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
mesendoderm development IEA
Inferred from Electronic Annotation
more info
 
mesendoderm development ISO
Inferred from Sequence Orthology
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neural crest cell development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell development ISO
Inferred from Sequence Orthology
more info
 
neural plate mediolateral regionalization IEA
Inferred from Electronic Annotation
more info
 
neural plate mediolateral regionalization ISO
Inferred from Sequence Orthology
more info
 
neural plate pattern specification ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
palate development IEA
Inferred from Electronic Annotation
more info
 
palate development ISO
Inferred from Sequence Orthology
more info
 
paraxial mesoderm development ISO
Inferred from Sequence Orthology
more info
 
paraxial mesoderm structural organization IEA
Inferred from Electronic Annotation
more info
 
paraxial mesoderm structural organization ISO
Inferred from Sequence Orthology
more info
 
pattern specification process ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of SMAD protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of lateral mesodermal cell fate specification IEA
Inferred from Electronic Annotation
more info
 
regulation of lateral mesodermal cell fate specification ISO
Inferred from Sequence Orthology
more info
 
signal transduction by phosphorylation IEA
Inferred from Electronic Annotation
more info
 
somitogenesis IEA
Inferred from Electronic Annotation
more info
 
somitogenesis ISO
Inferred from Sequence Orthology
more info
 
stem cell maintenance IEA
Inferred from Electronic Annotation
more info
 
stem cell maintenance ISO
Inferred from Sequence Orthology
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
caveola IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
bone morphogenetic protein receptor type-1A
Names
bone morphogenetic protein receptor type-1A
ALK-3
BMP type-1A receptor
BMPR-1A
activin receptor-like kinase 3
bone morphogenetic protein 4 receptor
bone morphogenetic protein receptor, type 1A
NP_110476.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030849.1NP_110476.1  bone morphogenetic protein receptor type-1A precursor

    See proteins identical to NP_110476.1

    Status: PROVISIONAL

    Source sequence(s)
    S75359
    UniProtKB/Swiss-Prot
    Q78EA7
    Related
    ENSRNOP00000015047, ENSRNOT00000015047
    Conserved Domains (3) summary
    pfam00069
    Location:237519
    Pkinase; Protein kinase domain
    pfam01064
    Location:59138
    Activin_recp; Activin types I and II receptor domain
    cd14220
    Location:238524
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    10758526..10802512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    5436477..5480314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)