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LSG1 large 60S subunit nuclear export GTPase 1 [ Homo sapiens (human) ]

Gene ID: 55341, updated on 26-Nov-2014
Official Symbol
LSG1provided by HGNC
Official Full Name
large 60S subunit nuclear export GTPase 1provided by HGNC
Primary source
HGNC:HGNC:25652
See related
Ensembl:ENSG00000041802; HPRD:07748; MIM:610780; Vega:OTTHUMG00000156021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
See LSG1 in Epigenomics, MapViewer
Location:
3q29
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (194640788..194672477, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194361517..194393206, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene Neighboring gene TMEM44 antisense RNA 1 Neighboring gene transmembrane protein 44 Neighboring gene family with sequence similarity 43, member A Neighboring gene uncharacterized LOC100507391 Neighboring gene family with sequence similarity 151, member A pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11301, FLJ27294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
GTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
GTP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nuclear export IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
large subunit GTPase 1 homolog
Names
large subunit GTPase 1 homolog
hLsg1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018385.2NP_060855.2  large subunit GTPase 1 homolog

    See proteins identical to NP_060855.2

    Status: REVIEWED

    Source sequence(s)
    AC046143, AW748476, BC040119, BC068500, BQ009975, DA101432, DA414880
    Consensus CDS
    CCDS33922.1
    UniProtKB/Swiss-Prot
    Q9H089
    Related
    ENSP00000265245, OTTHUMP00000209073, ENST00000265245, OTTHUMT00000342740
    Conserved Domains (3) summary
    cd01857
    Location:163444
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:151554
    COG1161; Predicted GTPases [General function prediction only]
    cl17170
    Location:366404
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    194640788..194672477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    194324597..194355945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    191741919..191772993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)