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    HSPA14 heat shock protein family A (Hsp70) member 14 [ Homo sapiens (human) ]

    Gene ID: 51182, updated on 8-Aug-2016
    Official Symbol
    HSPA14provided by HGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 14provided by HGNC
    Primary source
    HGNC:HGNC:29526
    See related
    Ensembl:ENSG00000187522 HPRD:07021; MIM:610369; Vega:OTTHUMG00000191882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP70-4; HSP70L1
    Orthologs
    Location:
    10p13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (14838160..14871741)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14880159..14913740)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107 member B Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene zinc finger and SCAN domain containing 29 pseudogene Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene suppressor of variegation 3-9 homolog 2 Neighboring gene DNA cross-link repair 1C Neighboring gene uncharacterized LOC105376430 Neighboring gene meiosis/spermiogenesis associated 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of heat shock 70kDa protein 14 (HSPA14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
    env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
    Pr55(Gag) gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
    gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC131990

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    'de novo' cotranslational protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    heat shock 70 kDa protein 14
    Names
    HSP70-like protein 1
    heat shock 70kDa protein 14 isoform 1 variant 3
    heat shock protein HSP60
    heat shock protein hsp70-related protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278205.1NP_001265134.1  heat shock 70 kDa protein 14 isoform 3

      See identical proteins and their annotated locations for NP_001265134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' exon in place of the last several exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC026226, BC038845, BP201211
      Consensus CDS
      CCDS60487.1
      UniProtKB/TrEMBL
      B0YIZ1, Q8TAQ0
      Related
      ENSP00000390513, OTTHUMP00000019162, ENST00000437161, OTTHUMT00000046912
      Conserved Domains (1) summary
      cl17037
      Location:274
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_016299.3NP_057383.2  heat shock 70 kDa protein 14 isoform 1

      See identical proteins and their annotated locations for NP_057383.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AF112210, BC119690, BP201211
      Consensus CDS
      CCDS7103.1
      UniProtKB/Swiss-Prot
      Q0VDF9
      Related
      ENSP00000367623, OTTHUMP00000019161, ENST00000378372, OTTHUMT00000046910
      Conserved Domains (1) summary
      cd10238
      Location:2376
      HSPA14-like_NBD; Nucleotide-binding domain of human HSPA14 and similar proteins

    RNA

    1. NR_103464.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains two alternate 3' exons in place of the last several exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC026226, BC108738, BP201211

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      14838160..14871741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      14880558..14914138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037538.1: Suppressed sequence

      Description
      NM_001037538.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.