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    Disc1 disrupted in schizophrenia 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307940, updated on 30-Jun-2015
    Official Symbol
    Disc1provided by RGD
    Official Full Name
    disrupted in schizophrenia 1provided by RGD
    Primary source
    RGD:631359
    See related
    Ensembl:ENSRNOG00000019779
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Summary
    interacts with a variety of cytoskeletal proteins; truncated mutant form is associated with Schizophrenia [RGD, Feb 2006]
    Orthologs
    See Disc1 in MapViewer
    Location:
    19q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57818865..58069992)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (68529791..68641620) , (68711386..68769050)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27-like Neighboring gene translin-associated factor X Neighboring gene similar to 40S ribosomal protein S25 Neighboring gene spore coat protein SP65-like Neighboring gene signal-induced proliferation-associated 1 like 2 Neighboring gene SET nuclear proto-oncogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cytoskeletal protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    kinesin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex scaffold ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation in forebrain IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation in forebrain ISO
    Inferred from Sequence Orthology
    more info
     
    cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    nonmotile primary cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to centrosome IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pyramidal neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse maturation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary base ISO
    Inferred from Sequence Orthology
    more info
     
    dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    disrupted in schizophrenia 1 homolog
    Names
    disrupted in schizophrenia 1 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175596.2NP_783186.2  disrupted in schizophrenia 1 homolog

      See identical proteins and their annotated locations for NP_783186.2

      Status: PROVISIONAL

      Source sequence(s)
      AY177674
      UniProtKB/Swiss-Prot
      Q810H6
      Related
      ENSRNOP00000054753, ENSRNOT00000057945
      Conserved Domains (1) summary
      TIGR02168
      Location:349621
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      57818865..58069992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772616.1XP_008770838.1  

      See identical proteins and their annotated locations for XP_008770838.1

      UniProtKB/Swiss-Prot
      Q810H6
      Conserved Domains (1) summary
      TIGR02168
      Location:349621
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      52376528..52580211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)