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    OTUD7B OTU deubiquitinase 7B [ Homo sapiens (human) ]

    Gene ID: 56957, updated on 3-Jul-2016
    Official Symbol
    OTUD7Bprovided by HGNC
    Official Full Name
    OTU deubiquitinase 7Bprovided by HGNC
    Primary source
    HGNC:HGNC:16683
    See related
    Ensembl:ENSG00000264522 HPRD:10313; MIM:611748; Vega:OTTHUMG00000012291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZA20D1; CEZANNE
    Orthologs
    Location:
    1q21.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (149940330..150010766, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149912229..149982686, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene splicing factor 3b subunit 4 Neighboring gene myotubularin related protein 11 Neighboring gene uncharacterized LOC105371427 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene vacuolar protein sorting 45 homolog

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Regulation of TNFR1 signaling, organism-specific biosystem (from REACTOME)
      Regulation of TNFR1 signaling, organism-specific biosystemTumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • TNF signaling, organism-specific biosystem (from REACTOME)
      TNF signaling, organism-specific biosystemThe inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) is expressed in immune and nonimmune cell types including macrophages, T cells, mast cells, granulocytes, natural killer (NK) cells, ...
    • TNFR1-induced NFkappaB signaling pathway, organism-specific biosystem (from REACTOME)
      TNFR1-induced NFkappaB signaling pathway, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce inflammation, cell proliferation, survival or cell death (Ward C et al. 1999; Michea...
    • TNFR1-induced proapoptotic signaling, organism-specific biosystem (from REACTOME)
      TNFR1-induced proapoptotic signaling, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce cell survival or cell death (Ward C et al. 1999; Micheau O and Tschopp J 2003; Wider...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    K63-linked polyubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Lys48-specific deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    OTU domain-containing protein 7B
    Names
    OTU domain containing 7B
    cellular zinc finger anti-NF-kappa-B protein
    cellular zinc finger anti-NF-kappaB Cezanne
    zinc finger A20 domain-containing protein 1
    zinc finger protein Cezanne
    zinc finger, A20 domain containing 1
    NP_064590.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020205.3NP_064590.2  OTU domain-containing protein 7B

      See identical proteins and their annotated locations for NP_064590.2

      Status: VALIDATED

      Source sequence(s)
      AC244033, BC015719, BC072681, BP321045, T51077
      Consensus CDS
      CCDS72903.1
      UniProtKB/Swiss-Prot
      Q6GQQ9
      Related
      ENSP00000462729, OTTHUMP00000275813, ENST00000581312, OTTHUMT00000034146
      Conserved Domains (3) summary
      pfam01754
      Location:801823
      zf-A20; A20-like zinc finger
      pfam02338
      Location:190359
      OTU; OTU-like cysteine protease
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      149940330..150010766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509784.2XP_011508086.1  

      See identical proteins and their annotated locations for XP_011508086.1

      Conserved Domains (3) summary
      pfam01754
      Location:810832
      zf-A20; A20-like zinc finger
      pfam02338
      Location:190359
      OTU; OTU-like cysteine protease
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    2. XM_011509788.1XP_011508090.1  

      See identical proteins and their annotated locations for XP_011508090.1

      Conserved Domains (2) summary
      pfam01754
      Location:731753
      zf-A20; A20-like zinc finger
      pfam02338
      Location:111280
      OTU; OTU-like cysteine protease
    3. XM_017001851.1XP_016857340.1  

    4. XM_017001850.1XP_016857339.1  

    5. XM_011509786.1XP_011508088.1  

      See identical proteins and their annotated locations for XP_011508088.1

      Conserved Domains (2) summary
      pfam01754
      Location:731753
      zf-A20; A20-like zinc finger
      pfam02338
      Location:111280
      OTU; OTU-like cysteine protease
    6. XM_011509782.1XP_011508084.1  

      See identical proteins and their annotated locations for XP_011508084.1

      Conserved Domains (3) summary
      pfam01754
      Location:810832
      zf-A20; A20-like zinc finger
      pfam02338
      Location:190359
      OTU; OTU-like cysteine protease
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    7. XM_011509785.2XP_011508087.1  

      See identical proteins and their annotated locations for XP_011508087.1

      Conserved Domains (3) summary
      pfam01754
      Location:810832
      zf-A20; A20-like zinc finger
      pfam02338
      Location:190359
      OTU; OTU-like cysteine protease
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    8. XM_011509787.1XP_011508089.1  

      See identical proteins and their annotated locations for XP_011508089.1

      Conserved Domains (2) summary
      pfam01754
      Location:731753
      zf-A20; A20-like zinc finger
      pfam02338
      Location:111280
      OTU; OTU-like cysteine protease
    9. XM_011509783.2XP_011508085.1  

      See identical proteins and their annotated locations for XP_011508085.1

      Conserved Domains (3) summary
      pfam01754
      Location:810832
      zf-A20; A20-like zinc finger
      pfam02338
      Location:190359
      OTU; OTU-like cysteine protease
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      151308456..151378863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)