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Ube2b ubiquitin-conjugating enzyme E2B [ Mus musculus (house mouse) ]

Gene ID: 22210, updated on 21-Feb-2015
Official Symbol
Ube2bprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Bprovided by MGI
Primary source
MGI:MGI:102944
See related
Ensembl:ENSMUSG00000020390; Vega:OTTMUSG00000005613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HR6B; Rad6b; mHR6B; E2-14k; 2610301N02Rik
Orthologs
See Ube2b in MapViewer
Location:
11; 11 B1.3
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (51985146..52002087, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105244162 Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene cyclin-dependent kinase-like 3 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Neighboring gene predicted gene, 30631 Neighboring gene microRNA 3061

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IGI
Inferred from Genetic Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-like protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
chiasma assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H2A ubiquitination ISO
Inferred from Sequence Orthology
more info
 
histone lysine demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
maintenance of chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
postreplication repair ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of histone modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to UV ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptonemal complex organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
HULC complex ISO
Inferred from Sequence Orthology
more info
 
XY body IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
replication fork ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ubiquitin-conjugating enzyme E2 B
Names
ubiquitin-conjugating enzyme E2 B
E214K
RAD6 homolog B
ubiquitin carrier protein B
ubiquitin-conjugating enzyme E2B, RAD6 homology
ubiquitin-protein ligase B
NP_033484.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009458.4NP_033484.3  ubiquitin-conjugating enzyme E2 B

    See proteins identical to NP_033484.3

    Status: VALIDATED

    Source sequence(s)
    AK147785, AK169229, BE944184
    Consensus CDS
    CCDS24664.1
    UniProtKB/TrEMBL
    A2RSE4
    UniProtKB/Swiss-Prot
    P63147
    Related
    ENSMUSP00000020657, OTTMUSP00000005786, ENSMUST00000020657, OTTMUST00000012488
    Conserved Domains (2) summary
    COG5078
    Location:1151
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7141
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    51985146..52002087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248967.1XP_011247269.1  

    See proteins identical to XP_011247269.1

    Conserved Domains (2) summary
    COG5078
    Location:1151
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7141
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_006533160.2XP_006533223.1  

    See proteins identical to XP_006533223.1

    UniProtKB/TrEMBL
    A2RSE4
    UniProtKB/Swiss-Prot
    P63147
    Conserved Domains (2) summary
    COG5078
    Location:1151
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7141
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. XM_006533161.2XP_006533224.1  

    See proteins identical to XP_006533224.1

    Conserved Domains (1) summary
    cd00195
    Location:7111
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    56553448..56568767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)