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MYO18B myosin XVIIIB [ Homo sapiens (human) ]

Gene ID: 84700, updated on 13-Sep-2014
Official Symbol
MYO18Bprovided by HGNC
Official Full Name
myosin XVIIIBprovided by HGNC
Primary source
HGNC:HGNC:18150
Locus tag
CTA-109D1.1
See related
Ensembl:ENSG00000133454; HPRD:09529; MIM:607295; Vega:OTTHUMG00000151129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
See MYO18B in Epigenomics, MapViewer
Location:
22q12.1
Exon count:
48
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 22 NC_000022.11 (25742147..26057379)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (26138117..26453345)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene adrenergic, beta, receptor kinase 2 Neighboring gene YES1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 494 Neighboring gene uncharacterized LOC102724801 Neighboring gene seizure related 6 homolog (mouse)-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.
NHGRI GWA Catalog
A genome-wide association study of serum uric acid in African Americans.
NHGRI GWA Catalog
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ41942, DKFZp434C2422, DKFZp779C1668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
sarcomere IEA
Inferred from Electronic Annotation
more info
 
unconventional myosin complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
unconventional myosin-XVIIIb
Names
unconventional myosin-XVIIIb
myosin 18B
myosin-XVIIIb

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032608.5NP_115997.5  unconventional myosin-XVIIIb

    See proteins identical to NP_115997.5

    Status: REVIEWED

    Source sequence(s)
    AB075376, AJ310931
    Consensus CDS
    CCDS54507.1
    UniProtKB/Swiss-Prot
    Q8IUG5
    Related
    ENSP00000334563, OTTHUMP00000198632, ENST00000335473, OTTHUMT00000320371
    Conserved Domains (5) summary
    pfam03157
    Location:63499
    Blast Score: 134
    Glutenin_hmw; High molecular weight glutenin subunit
    COG5022
    Location:5102086
    Blast Score: 714
    COG5022; Myosin heavy chain [Cytoskeleton]
    cd01386
    Location:5721332
    Blast Score: 3297
    MYSc_type_XVIII; Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and ...
    cl12013
    Location:17001791
    Blast Score: 91
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19113
    Location:18001949
    Blast Score: 100
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000022.11 

    Range
    25742147..26057379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724341.1XP_006724404.1  

    Conserved Domains (2) summary
    pfam03157
    Location:63499
    Blast Score: 126
    Glutenin_hmw; High molecular weight glutenin subunit
    cd01386
    Location:5721333
    Blast Score: 3305
    MYSc_type_XVIII; Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and ...
  2. XM_005261787.2XP_005261844.1  

    See proteins identical to XP_005261844.1

    UniProtKB/TrEMBL
    F5GXR6
    Conserved Domains (5) summary
    pfam03157
    Location:63499
    Blast Score: 132
    Glutenin_hmw; High molecular weight glutenin subunit
    COG5022
    Location:5102087
    Blast Score: 713
    COG5022; Myosin heavy chain [Cytoskeleton]
    cd01386
    Location:5721333
    Blast Score: 3287
    MYSc_type_XVIII; Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and ...
    cl12013
    Location:17011792
    Blast Score: 91
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19113
    Location:18011950
    Blast Score: 100
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. XM_005261786.2XP_005261843.1  

    See proteins identical to XP_005261843.1

    UniProtKB/TrEMBL
    F5GXR6
    Related
    ENSP00000386096, OTTHUMP00000239236, ENST00000407587, OTTHUMT00000400691
    Conserved Domains (5) summary
    pfam03157
    Location:63499
    Blast Score: 132
    Glutenin_hmw; High molecular weight glutenin subunit
    COG5022
    Location:5102087
    Blast Score: 713
    COG5022; Myosin heavy chain [Cytoskeleton]
    cd01386
    Location:5721333
    Blast Score: 3287
    MYSc_type_XVIII; Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and ...
    cl12013
    Location:17011792
    Blast Score: 91
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19113
    Location:18011950
    Blast Score: 100
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  4. XM_005261788.2XP_005261845.1  

    See proteins identical to XP_005261845.1

    UniProtKB/TrEMBL
    F5GXR6
    Conserved Domains (5) summary
    pfam03157
    Location:63499
    Blast Score: 132
    Glutenin_hmw; High molecular weight glutenin subunit
    COG5022
    Location:5102087
    Blast Score: 713
    COG5022; Myosin heavy chain [Cytoskeleton]
    cd01386
    Location:5721333
    Blast Score: 3287
    MYSc_type_XVIII; Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and ...
    cl12013
    Location:17011792
    Blast Score: 91
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19113
    Location:18011950
    Blast Score: 100
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  5. XM_006724340.1XP_006724403.1  

    Conserved Domains (4) summary
    COG5022
    Location:3911968
    Blast Score: 718
    COG5022; Myosin heavy chain [Cytoskeleton]
    cd01386
    Location:4531214
    Blast Score: 3287
    MYSc_type_XVIII; Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and ...
    cl12013
    Location:15821673
    Blast Score: 91
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19113
    Location:16821831
    Blast Score: 100
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate HuRef

Genomic

  1. AC_000154.1 

    Range
    9085589..9374875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 

    Range
    26097561..26386572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)