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Rps6ka2 ribosomal protein S6 kinase polypeptide 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117269, updated on 12-Feb-2015
Official Symbol
Rps6ka2provided by RGD
Official Full Name
ribosomal protein S6 kinase polypeptide 2provided by RGD
Primary source
RGD:620676
See related
Ensembl:ENSRNOG00000013194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
ribosomal protein; may be upregulated by the insulin signaling pathway in skeletal muscle [RGD, Feb 2006]
Orthologs
See Rps6ka2 in MapViewer
Location:
1q11
Exon count:
22
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (53329913..53499445)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (54469155..54747731)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene Fgfr1 oncogene partner Neighboring gene ribonuclease T2 Neighboring gene G protein-coupled receptor 31 Neighboring gene t-complex protein 10b

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
ribosomal protein S6 kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
brain renin-angiotensin system IEA
Inferred from Electronic Annotation
more info
 
brain renin-angiotensin system ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to carbohydrate stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to carbohydrate stimulus ISO
Inferred from Sequence Orthology
more info
 
heart contraction IEA
Inferred from Electronic Annotation
more info
 
heart contraction ISO
Inferred from Sequence Orthology
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
oocyte maturation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
regulation of protein processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
ribosome IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 
spindle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ribosomal protein S6 kinase alpha-2
Names
ribosomal protein S6 kinase alpha-2
ribosomal protein S6 kinase, 90kD, polypeptide 2
NP_476469.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057128.1NP_476469.1  ribosomal protein S6 kinase alpha-2

    See proteins identical to NP_476469.1

    Status: VALIDATED

    Source sequence(s)
    AABR07001574, AABR07001576
    UniProtKB/TrEMBL
    F1M7N7
    Related
    ENSRNOP00000017809, ENSRNOT00000017809
    Conserved Domains (3) summary
    smart00220
    Location:59318
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:63379
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:411703
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    53329913..53499445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006227917.2XP_006227979.1  

    Conserved Domains (3) summary
    smart00220
    Location:43302
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:47363
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:395687
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    48533427..48667077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)