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EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 [ Homo sapiens (human) ]

Gene ID: 8637, updated on 13-Jan-2015
Official Symbol
EIF4EBP3provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E binding protein 3provided by HGNC
Primary source
HGNC:HGNC:3290
See related
Ensembl:ENSG00000243056; HPRD:09149; MIM:603483; Vega:OTTHUMG00000129498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4EBP3; 4E-BP3
Summary
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
Orthologs
See EIF4EBP3 in MapViewer
Location:
5q31.3
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (140547666..140549578)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139927251..139929163)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 9 Neighboring gene ANKHD1-EIF4EBP3 readthrough Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene steroid receptor RNA activator 1 Neighboring gene microRNA 6831 Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough ANKHD1-EIF4EBP3

Readthrough gene: ANKHD1-EIF4EBP3, Included gene: ANKHD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
eukaryotic initiation factor 4E binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation repressor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eukaryotic translation initiation factor 4E-binding protein 3
Names
eukaryotic translation initiation factor 4E-binding protein 3
eIF4E-binding protein 3
eukaryotic initiation factor 4E-binding protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003732.2NP_003723.1  eukaryotic translation initiation factor 4E-binding protein 3

    See proteins identical to NP_003723.1

    Status: REVIEWED

    Source sequence(s)
    AF038869, BC010881
    Consensus CDS
    CCDS4226.1
    UniProtKB/Swiss-Prot
    O60516
    Related
    ENSP00000308472, OTTHUMP00000159879, ENST00000310331, OTTHUMT00000251668
    Conserved Domains (1) summary
    pfam05456
    Location:4100
    eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    140547666..140549578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    139360499..139362411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    135072590..135074502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)