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Mapk14 mitogen activated protein kinase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81649, updated on 6-May-2015
Official Symbol
Mapk14provided by RGD
Official Full Name
mitogen activated protein kinase 14provided by RGD
Primary source
RGD:70496
See related
Ensembl:ENSRNOG00000000513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
RK; Hog; p38; CRK1; CSBP; Exip; Mxi2; CSPB1; Csbp1; Csbp2; Prkm14; Prkm15; Sapk2A; p38Hog; p38alpha
Summary
mitogen-activated protein kinase; involved in intracellular signalling, inhibition of apoptosis and gene activation [RGD, Feb 2006]
Orthologs
See Mapk14 in MapViewer
Location:
20p12
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5933303..5995137)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (7968528..8028708)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene SRSF protein kinase 1 Neighboring gene solute carrier family 26 (anion exchanger), member 8 Neighboring gene uncharacterized LOC102555910 Neighboring gene mitogen activated protein kinase 13 Neighboring gene bromodomain and PHD finger containing, 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC105413

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
MAP kinase activity TAS
Traceable Author Statement
more info
PubMed 
NFAT protein binding IEA
Inferred from Electronic Annotation
more info
 
NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cartilage condensation IEA
Inferred from Electronic Annotation
more info
 
cartilage condensation ISO
Inferred from Sequence Orthology
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
 
fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
myoblast differentiation involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
myoblast differentiation involved in skeletal muscle regeneration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
placenta development ISO
Inferred from Sequence Orthology
more info
 
NOT positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast fusion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to muramyl dipeptide IEA
Inferred from Electronic Annotation
more info
 
response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
signal transduction in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
stress-induced premature senescence IEA
Inferred from Electronic Annotation
more info
 
stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
spindle pole ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
mitogen-activated protein kinase 14
Names
mitogen-activated protein kinase 14
Csaids binding protein
MAP kinase 14
MAP kinase 2
MAP kinase Mxi2
MAP kinase p38 alpha
MAPK 14
MAX-interacting protein 2
cytokine suppressive anti-inflammatory drug binding protein
cytokine-supressive anti-inflammatory drug binding protein
mitogen-activated protein kinase 14A
mitogen-activated protein kinase p38 alpha
p38 MAP kinase
p38 mitogen activated protein kinase
p38alpha Exip
reactive kinase
stress-activated protein kinase 2A
NP_112282.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031020.2NP_112282.2  mitogen-activated protein kinase 14

    See identical proteins and their annotated locations for NP_112282.2

    Status: PROVISIONAL

    Source sequence(s)
    BC092193
    UniProtKB/TrEMBL
    Q56A33
    Related
    ENSRNOP00000000617, ENSRNOT00000000617
    Conserved Domains (2) summary
    cd07877
    Location:6350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    smart00220
    Location:24308
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    5933303..5995137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256142.2XP_006256204.1  

    See identical proteins and their annotated locations for XP_006256204.1

    UniProtKB/TrEMBL
    G3V617
    Related
    ENSRNOP00000000618
    Conserved Domains (2) summary
    cd07877
    Location:6350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    smart00220
    Location:24308
    S_TKc; Serine/Threonine protein kinases, catalytic domain

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    8305853..8366371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)